Title: Dibromopropamidine
CAS Registry Number: 496-00-4
CAS Name: 4,4¢-[1,3-Propanediylbis(oxy)]bis(3-bromobenzenecarboximidamide)
Additional Names: 4,4¢-(trimethylenedioxy)bis(3-bromobenzamidine); 2¢,2¢¢-dibromo-4¢,4¢¢-diamidino-1,3-diphenoxypropane
Molecular Formula: C17H18Br2N4O2
Molecular Weight: 470.16
Percent Composition: C 43.43%, H 3.86%, Br 33.99%, N 11.92%, O 6.81%
Literature References: Prepn: S. S. Berg, G. Newbery, GB 598911 (1948 to May & Baker); eidem, J. Chem. Soc. 1949, 642. Antibacterial activity: R. Wien et al., Lancet 254, 711 (1948); A. D. Russell, J. R. Furr, Int. J. Pharm. 34, 115 (1986). Mode of action: W. Woodside, Microbios 8, 23 (1973). Clinical use in Acanthamoeba keratitis: J. J. Wiens, W. B. Jackson, Can. J. Ophthalmol. 23, 107 (1988). HPLC determn in cosmetics: B. Wyhowski de Bukanski, M. O. Masse, Int. J. Cosmet. Sci. 6, 283 (1984).
Derivative Type: Isethionate
CAS Registry Number: 614-87-9
Trademarks: Brolene Ointment (RPR); Brulidine (M & B)
Molecular Formula: C21H30Br2N4O10S2
Molecular Weight: 722.42
Percent Composition: C 34.91%, H 4.19%, Br 22.12%, N 7.76%, O 22.15%, S 8.88%
Properties: Prismatic needles from ethanol, mp 226°. Freely sol in water. One gram dissolves in 2 ml of water at 20°, in 60 g of 95% alcohol at 20°. Sol in glycerol. Practically insol in ether, chloroform, fixed oils, liquid petrolatum. Aq solns are very slightly acidic. Solns may be sterilized by heating at 100° for 30 min, but they should not be stored for more than a few days, and then only in neutral glass containers since some hydrolysis occurs with the formation of sparingly sol urea derivs. Incompat. with chlorides, sulfates, and many organic anions, all of which form sparingly sol salts.
Melting point: mp 226°
Use: Preservative in cosmetics.
Therap-Cat: Antiseptic; antiamebic.
Therap-Cat-Vet: Antiseptic, antimicrobial.
Keywords: Antiamebic; Antiseptic/Disinfectant.
Dibromsalicil Dibucaine Dibutoline Sulfate Dibutyl Phthalate Dibutyl Succinate

CAS number 496-00-4
PubChem 11974
ChemSpider 11479 YesY
KEGG D07204 YesY
ATC code D08AC01,S01AX14
Jmol-3D images Image 1
Image 2
Molecular formula C17H18Br2N4O2
Molar mass 470.16 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Dibrompropamidine is an antiseptic and disinfectant. As dibrompropamidine isethionate, it is used in eyedrops and ointment for the treatment of minor eye and eyelid infections in adults and children. In the UK, such preparations are sold under the brand names Brolene (Aventis Pharma), Golden Eye (Typharm Ltd) and Brulidine (Manx Healthcare).