Dicapthon

Title: Dicapthon
CAS Registry Number: 2463-84-5
CAS Name: Phosphorothioic acid O-(2-chloro-4-nitrophenyl) O,O-dimethyl ester
Additional Names: O,O-dimethyl O-(2-chloro-4-nitrophenyl)phosphorothioate; O,O-dimethyl-O-(2-chloro-4-nitrophenyl)thionophosphate; p-nitro-o-chlorophenyl dimethyl thionophosphate; isochlorothion
Manufacturers' Codes: American Cyanamid 4124; insecticide ACC 4124
Trademarks: Dicaptan
Molecular Formula: C8H9ClNO5PS
Molecular Weight: 297.65
Percent Composition: C 32.28%, H 3.05%, Cl 11.91%, N 4.71%, O 26.88%, P 10.41%, S 10.77%
Literature References: Prepn: J. H. Fletcher, US 2664437; Geoghegan, McPherson, US 2784207 (1953, 1957 both to Am. Cyanamid); Schrader, Angew. Chem. 66, 265 (1954); idem, Die Entwicklung neuer insektizider Phosphorsäure-Ester (Verlag Chemie, 3rd ed., 1963) pp 289-291. Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).
Properties: Crystals from methanol, mp 53°. Sol in acetone, cyclohexanone, ethyl acetate, toluene, xylene, ethylene glycol, propylene glycol, some oils. Practically insol in water. LD50 in male, female rats (mg/kg): 400, 330 orally; 790, 1250 dermally (Gaines).
Melting point: mp 53°
Toxicity data: LD50 in male, female rats (mg/kg): 400, 330 orally; 790, 1250 dermally (Gaines)
CAUTION: Cholinesterase inhibitor.
Use: Insecticide.
Status: This monograph has been retired and is no longer subject to revision or update.
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