Dichloroacetic Acid

Title: Dichloroacetic Acid
CAS Registry Number: 79-43-6
Additional Names: Bichloracetic acid; dichlorethanoic acid; DCA
Molecular Formula: C2H2Cl2O2
Molecular Weight: 128.94
Percent Composition: C 18.63%, H 1.56%, Cl 54.99%, O 24.82%
Line Formula: CHCl2COOH
Literature References: Transformation of chloral to dichloroacetic acid: Wallach, Ann. 173, 288 (1874); Frantzen, Fikentscher, ibid. 623, 68 (1959); Rosenblum et al., Chem. Ind. (London) 1960, 718. Toxicity: Smyth et al., Arch. Ind. Hyg. Occup. Med. 4, 119 (1951); P. W. Stacpoole et al., N. Engl. J. Med. 300, 372 (1979); J. L. Cicmanec et al., Fundam. Appl. Toxicol. 17, 376 (1991). Mutagenicity studies: V. Herbert et al., Am. J. Clin. Nutr. 33, 1179 (1980). Use in treatment of lactic acidosis: P. W. Stacpoole et al., N. Engl. J. Med. 309, 390 (1983).
Properties: Liquid; pungent odor. d420 1.563. bp 193-194°. Apparently occurs in two cryst forms, mp 9.7° and -4°. nD22 1.4659. Miscible with water, alc, ether. LD50 orally in rats: 2.82 g/kg (Smyth).
Melting point: mp 9.7° and -4°
Boiling point: bp 193-194°
Index of refraction: nD22 1.4659
Density: d420 1.563
Toxicity data: LD50 orally in rats: 2.82 g/kg (Smyth)
Derivative Type: Ethyl ester
Molecular Formula: C4H6Cl2O2
Molecular Weight: 157.00
Percent Composition: C 30.60%, H 3.85%, Cl 45.16%, O 20.38%
Properties: Liquid, bp 158.3-158.7°. d420 1.282. nD20 1.4386. Slightly sol in water; miscible with alcohol, ether.
Boiling point: bp 158.3-158.7°
Index of refraction: nD20 1.4386
Density: d420 1.282
Therap-Cat: Caustic; keratolytic; topical astringent.
Keywords: Astringent; Keratolytic.
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