Diethazine

Title: Diethazine
CAS Registry Number: 60-91-3
CAS Name: N,N-Diethyl-10H-phenothiazine-10-ethanamine
Additional Names: 10-(2-diethylaminoethyl)phenothiazine; N-(diethylaminoethyl)thiodiphenylamine; N-(2¢-diethylaminoethyl)dibenzoparathiazine
Manufacturers' Codes: RP-2987
Trademarks: Deparkin; Dinezin; Dolisina; Eazaminum; Ethylemin; Parkazin
Molecular Formula: C18H22N2S
Molecular Weight: 298.45
Percent Composition: C 72.44%, H 7.43%, N 9.39%, S 10.74%
Literature References: Anticholinergic. Prepd by reacting 10-phenothiazineethyl chloride with diethylamine in presence of copper powder or by reacting diethylaminoethyl chloride with phenothiazine: Charpentier, Compt. Rend. 225, 306 (1947); Huttrer, Enzymologia 12, 293 (1948); Charpentier, US 2530451 (1950 to Rhône-Poulenc); Berg, Ashley, US 2607773 (1952 to Rhône-Poulenc). Toxicity study: Bovet et al., Therapie 2, 115 (1947).
Properties: Oily liquid. bp4-5 195-208°; bp0.4-0.5 167-175°.
Boiling point: bp4-5 195-208°; bp0.4-0.5 167-175°
Derivative Type: Hydrochloride
CAS Registry Number: 341-70-8
Trademarks: Antipar (Farmitalia); Aparkazin; Diparcol (Specia); Latibon (Bayer); Thiantan; Thiontan
Molecular Formula: C18H22N2S.HCl
Molecular Weight: 334.91
Percent Composition: C 64.55%, H 6.92%, N 8.36%, S 9.57%, Cl 10.59%
Properties: Crystals, mp 184-186°. Burning taste, producing a temporary numbness of the tongue. One part dissolves in about 5 parts water, 6 parts ethanol, 5 parts chloroform. Practically insol in ether. pH of 10% aq soln 5.0-5.3. LD50 orally in mice: 450 mg/kg (Bovet).
Melting point: mp 184-186°
Toxicity data: LD50 orally in mice: 450 mg/kg (Bovet)
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Antimuscarinic.
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