Difenacoum

Title: Difenacoum
CAS Registry Number: 56073-07-5
CAS Name: 3-(3-[1,1¢-Biphenyl]-4-yl-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-[3-(biphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-4-hydroxycoumarin; 3-(3-p-biphenyl-1,2,3,4-tetrahydronaphth-1-yl)-4-hydroxycoumarin
Trademarks: Neosorexa (Sorex); Ratak (Sorex)
Molecular Formula: C31H24O3
Molecular Weight: 444.52
Percent Composition: C 83.76%, H 5.44%, O 10.80%
Literature References: Second generation anticoagulant rodenticide. Prepn: M. R. Hadler, R. S. Shadbolt, DE 2424806; idem, US 3957824 (1975, 1976 both to Ward Blenkinsop); R. S. Shadbolt et al., J. Chem. Soc. Perkin Trans. 1 1976, 1190. Comprehensive description: J. O. Bull, Proc. Vertebr. Pest Conf. 7, 72 (1976). HPLC determn of rat blood and liver: M. J. Kelly et al., J. Chromatogr. 620, 105 (1993); of residue levels in rats: H. Atterby et al., Environ. Toxicol. Chem. 24, 318 (2005). Field and laboratory studies against the house mouse: F. P. Rowe et al., J. Hyg. Camb. 87, 171 (1981). Pharmacokinetics and pharmacodynamics in rabbits: A. M. Breckenridge et al., Br. J. Pharmacol. 84, 81 (1985). Pharmacological variation between rodent sexes: M. J. Winn et al., J. Pharm. Pharmacol. 39, 219 (1987).
Properties: Crystals from ethyl acetate, mp 215-217°. LD50 orally in Wistar male, female rats (mg/kg): 1.8, 2.5; in male rabbits: 2.0 mg/kg; in dogs: 50 mg/kg; in cats: 100 mg/kg (Bull).
Melting point: mp 215-217°
Toxicity data: LD50 orally in Wistar male, female rats (mg/kg): 1.8, 2.5; in male rabbits: 2.0 mg/kg; in dogs: 50 mg/kg; in cats: 100 mg/kg
Use: Pesticide.
Difenamizole Difenoconazole Difenoxin Difenpiramide Difenzoquat

Difenacoum
Difenacoum structure.png
Identifiers
CAS number 56073-07-5 YesY
PubChem 41735
KEGG C16807 YesY
Jmol-3D images Image 1
Properties
Molecular formula C31H24O3
Molar mass 444.52 g/mol
Density 1.27 (98.7% w/w)
Melting point 211.0 – 215.0 °C (98.7% wlw)
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Difenacoum is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It has anticoagulant effects and is used commercially as a rodenticide.