Title: Diflorasone
CAS Registry Number: 2557-49-5
CAS Name: (6a,11b,16b)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 6a,9a-difluoro-16b-methyl-D1,4-pregnadiene-11b,17a,21-triol-3,20-dione; 6a,9a-difluoro-16b-methylprednisolone
Molecular Formula: C22H28F2O5
Molecular Weight: 410.45
Percent Composition: C 64.38%, H 6.88%, F 9.26%, O 19.49%
Literature References: The 16b-analog of flumethasone, q.v. Prepn of free alcohol and 21-acetate: GB 881334 (1961 to Pfizer), C.A. 56, 15586c (1962); GB 898293; F. H. Lincoln et al., US 3557158 (1962, 1971 both to Upjohn); GB 912015 (1962 to Merck & Co.). Prepn of the 17,21-diacetate: D. E. Ayer et al., DE 2308731; eidem, US 3980778 (1973, 1976 both to Upjohn). Proposed mechanism of action: S. Hammarstrom et al., Science 197, 994 (1977). Pharmacology: S. Wickrema et al., J. Invest. Dermatol. 71, 372 (1978). Clinical study: S. M. Bluefarb et al., J. Int. Med. Res. 4, 454 (1976).
Derivative Type: Diacetate
CAS Registry Number: 33564-31-7
Manufacturers' Codes: U-34865
Trademarks: Dermaflor (Brocchieri); Diacort (Pfizer); Florone (Pfizer); Maxiflor (Allergan); Psorcon (Dermik); Soriflor (Nycomed)
Molecular Formula: C26H32F2O7
Molecular Weight: 494.52
Percent Composition: C 63.15%, H 6.52%, F 7.68%, O 22.65%
Properties: Crystals from ethyl acetate-Skellysolve C and acetone-methanol, mp 221-223° (dec). uv max (alc): 238 nm (e 17250). [a]D +61° (chloroform).
Melting point: mp 221-223° (dec)
Optical Rotation: [a]D +61° (chloroform)
Absorption maximum: uv max (alc): 238 nm (e 17250)
Therap-Cat: Anti-inflammatory (topical); glucocorticoid.
Keywords: Glucocorticoid.
Difloxacin Diflubenzuron Diflucortolone Diflufenican Diflufenzopyr

Systematic (IUPAC) name
[17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
Clinical data
Trade names Psorcon
AHFS/Drugs.com monograph
MedlinePlus a602019
Pregnancy cat. C (US)
Legal status -only (US)
Routes Topical
CAS number 1-13-8 N
ATC code D07AC10
PubChem CID 71414
DrugBank DB00223
ChemSpider 64504 YesY
KEGG D01327 YesY
ChEBI CHEBI:31483 YesY
Chemical data
Formula C26H32F2O7 
Mol. mass 494.525 g/mol
 N (what is this?)  (verify)

Diflorasone is a topical steroid that comes in the form of a cream containing diflorasone diacetate. In is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class III steroid (of classes I–IV).[2]

No long-term animal studies have been done to determine whether diflorasone could have carcinogenic properties.

Little data is available regarding whether diflorasone would be present in great enough quantities to cause harm to an infant.[2]