Title: Difluprednate
CAS Registry Number: 23674-86-4
CAS Name: (6a,11b)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione
Additional Names: 6a,9-difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-butyrate; 6a,9a-difluoroprednisolone-21-acetate-17-butyrate
Manufacturers' Codes: CM-9155; W-6309
Trademarks: Epitopic (Gerda); Myser (Nikken)
Molecular Formula: C27H34F2O7
Molecular Weight: 508.55
Percent Composition: C 63.77%, H 6.74%, F 7.47%, O 22.02%
Literature References: Prepn: A. Ercoli, R. Gardi, ZA 6803686; A. Ercoli et al., US 3780177 (1968, 1973 both to Warner-Lambert). Anti-inflammatory properties: G. Di Pasquale et al., Steroids 16, 663, 679 (1970); R. Gardi et al., J. Med. Chem. 15, 556 (1972). Pharmacological study: J. Navarro et al., Arzneim.-Forsch. 28, 2302 (1978). Vasoconstrictive activity in man: A. Barbier et al., Therapie 33, 607 (1978). Bioavailability study: C. Lafille et al., Dermatologica 159, 277 (1979).
Properties: Crystals from methylene chloride/ether/petr ether, mp 191-194°. [a]D22 +31.7° (c = 0.5 in dioxane). uv max (ethanol): 237-238 nm (E1%1cm 320).
Melting point: mp 191-194°
Optical Rotation: [a]D22 +31.7° (c = 0.5 in dioxane)
Absorption maximum: uv max (ethanol): 237-238 nm (E1%1cm 320)
Therap-Cat: Anti-inflammatory.
Keywords: Glucocorticoid.
Digallic Acid Digalogenin Diginatigenin Diginatin Diginin

Systematic (IUPAC) name
[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a609025
Licence data US FDA:link
Legal status -only (US)
Routes topical dermatologic
CAS number 23674-86-4 YesY
ATC code D07AC19
PubChem CID 32037
DrugBank DB06781
ChemSpider 391990 N
KEGG D01266 YesY
Chemical data
Formula C27H34F2O7 
Mol. mass 508.551
 N (what is this?)  (verify)

Difluprednate is a corticosteroid, It is chemically a butyrate ester of 6(alpha),9(alpha)-difluoro prednisolone acetate. Accordingly, difluprednate is sometimes abbreviated DFBA, for difluoroprednisolone butyrate acetate.