Diisopropylamine Dichloroacetate

Title: Diisopropylamine Dichloroacetate
CAS Registry Number: 660-27-5
CAS Name: Dichloroacetic acid compd with N-(1-methylethyl)-2-propanamine (1:1)
Additional Names: dichloroacetic acid diisopropylammonium salt; diisopropylammonium dichloroacetate; diisopropylamine dichloroethanoate; DADA; DIPA-DCA; DIEDI
Manufacturers' Codes: IS-401
Trademarks: Disotat (Isis); Kalodil (Fidia); Oxypangam (Sanorania)
Molecular Formula: C8H17Cl2NO2
Molecular Weight: 230.13
Percent Composition: C 41.75%, H 7.45%, Cl 30.81%, N 6.09%, O 13.90%
Literature References: Prepn: GB 862248 (1961 to Italseber). Pharmacology: V. A. E. Kraushaar et al., Arzneim.-Forsch. 13, 109 (1963). Ames mutagenicity test: M. D. Gelernt, V. Herbert, Nutr. Cancer 3, 129 (1982). Pharmacokinetics and TLC determn in racehorses: J.-M. Yang et al., Gen. Pharmacol. 19, 683 (1988). Review of pharmacology: P. W. Stacpoole, J. Clin. Pharmacol. J. New Drugs 9, 282-291 (1969).
Properties: Crystals, mp 119-121°. Soly in water: >50%. LD50 orally in mice: 1700 mg/kg (Kraushaar).
Melting point: mp 119-121°
Toxicity data: LD50 orally in mice: 1700 mg/kg (Kraushaar)
Therap-Cat: Vasodilator, hypotensive.
Keywords: Vasodilator (Cerebral); Vasodilator (Peripheral).
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