Dimorpholamine

Title: Dimorpholamine
CAS Registry Number: 119-48-2
CAS Name: N,N¢-1,2-Ethanediylbis[N-butyl-4-morpholinecarboxamide]
Additional Names: N,N¢-dibutyl-N,N¢-dicarboxymorpholideethylenediamine; N,N¢-dibutyl-N,N¢-dicarboxyethylene diaminemorpholide
Manufacturers' Codes: TH-1064
Trademarks: Amipan T; Théraleptique; Theraptique
Molecular Formula: C20H38N4O4
Molecular Weight: 398.54
Percent Composition: C 60.27%, H 9.61%, N 14.06%, O 16.06%
Literature References: Prepn: Boon, J. Chem. Soc. 1947, 307; idem, US 2398283 and US 2409829 (both 1946 to I.C.I.). Toxicity data: Y. Kasé et al., Arch. Int. Pharmacodyn. Ther. 163, 133 (1966).
Properties: Crystals from petr ether, mp 41-42°. bp0.4 229°. Solubility in water: 50%. LD50 in mice (mg/10 g): 0.54 i.v.; 0.80 i.p.; 1.04 s.c.; 3.80 orally (Kasé).
Melting point: mp 41-42°
Boiling point: bp0.4 229°
Toxicity data: LD50 in mice (mg/10 g): 0.54 i.v.; 0.80 i.p.; 1.04 s.c.; 3.80 orally (Kasé)
Therap-Cat: Analeptic.
Keywords: Respiratory Stimulant.
Status: This monograph has been retired and is no longer subject to revision or update.
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