Dioxaphetyl Butyrate

Title: Dioxaphetyl Butyrate
CAS Registry Number: 467-86-7
CAS Name: a,a-Diphenyl-4-morpholinebutanoic acid ethyl ester
Additional Names: ethyl 4-morpholino-2,2-diphenylbutyrate; 4-morpholino-2,2-diphenylbutyric acid ethyl ester
Trademarks: Amidalgon; Spasmoxal(e)
Molecular Formula: C22H27NO3
Molecular Weight: 353.45
Percent Composition: C 74.76%, H 7.70%, N 3.96%, O 13.58%
Literature References: Prepn: Specter et al., J. Am. Chem. Soc. 71, 57 (1949); Dupré et al., J. Chem. Soc. 1949, 500; Bockmühl, Ehrhart, US 2230774 (1940 to Winthrop).
Derivative Type: Hydrochloride
Molecular Formula: C22H27NO3.HCl
Molecular Weight: 389.92
Percent Composition: C 67.77%, H 7.24%, N 3.59%, O 12.31%, Cl 9.09%
Properties: mp 168-169°.
Melting point: mp 168-169°
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.11.
Therap-Cat: Analgesic (narcotic). Antispasmodic.
Keywords: Analgesic (Narcotic); Antispasmodic.
Status: This monograph has been retired and is no longer subject to revision or update.
Dioxethedrine Dioxybenzone Dioxypyramidon Diperodon Hydrochloride Diphacinone

Dioxaphetyl butyrate
Systematic (IUPAC) name
Ethyl 4-morpholin-4-yl-2,2-di(phenyl)butanoate
Clinical data
Legal status Prohibited (S9) (AU) C (US)
Routes Oral, Other ROA Unknown
CAS number 467-86-7 YesY
ATC code None
PubChem CID 48194
Synonyms Amidalgon, Spasmoxal
Chemical data
Formula C22H27NO3 
Mol. mass 353.45 g/mol
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Dioxaphetyl butyrate (INN; trade names Amidalgon, Spasmoxal) is an opioid analgesic which is a diphenylacetic acid derivative, related to other open-chain opioid drugs such as dextropropoxyphene, levacetylmethadol (LAAM), lefetamine and dimenoxadol.

It produces similar effects to other opioids, including dependence, euphoria, analgesia, sedation, constipation, dizziness and nausea.