Title: Diphemethoxidine
CAS Registry Number: 13862-07-2
CAS Name: 2-(Diphenylmethyl)-1-piperidineethanol
Additional Names: 2-benzhydryl-1-piperidineethanol; 1-(b-hydroxyethyl)-2-(diphenylmethyl)piperidine
Manufacturers' Codes: Ba-18189
Trademarks: Cleofil (Ciba)
Molecular Formula: C20H25NO
Molecular Weight: 295.42
Percent Composition: C 81.31%, H 8.53%, N 4.74%, O 5.42%
Literature References: Prepn: GB 861815 (1961 to Ciba), C.A. 55, 15517h (1961).
Properties: mp 106-107°. bp0.1 180-181°.
Melting point: mp 106-107°
Boiling point: bp0.1 180-181°
Derivative Type: Hydrochloride
Properties: mp 166-167°.
Melting point: mp 166-167°
Therap-Cat: Anorexic.
Keywords: Anorexic.
Status: This monograph has been retired and is no longer subject to revision or update.
Diphenamid Diphenane Diphencyprone Diphenic Acid Diphenidol

Systematic (IUPAC) name
Clinical data
Legal status Withdrawn
Routes Oral
CAS number 13862-07-2
ATC code None
PubChem CID 65607
ChemSpider 59048
Chemical data
Formula C20H25NO 
Mol. mass 295.42 g/mol

Difemetorex (INN; sold as Cleofil), also known as diphemethoxidine, is a stimulant drug of the piperidine class which was used as an appetite suppressant, but produced intolerable side effects such as insomnia which limited its clinical use.[1][2][3][4][5] It was introduced in France by Ciba-Geigy in 1966 but is now no longer marketed.[6]