Disophenol

Title: Disophenol
CAS Registry Number: 305-85-1
CAS Name: 2,6-Diiodo-4-nitrophenol
Additional Names: DNP
Trademarks: Ancylol (Am. Cyanamid)
Molecular Formula: C6H3I2NO3
Molecular Weight: 390.90
Percent Composition: C 18.44%, H 0.77%, I 64.93%, N 3.58%, O 12.28%
Literature References: Prepd by iodination of p-nitrophenol with iodine/potassium iodide soln in aq ammonia: Datta, Prosad, J. Am. Chem. Soc. 39, 446 (1917). As an anthelmintic: Thorson et al., US 3081224 (1963 to Am. Cyanamid). Toxicity studies: J. A. Kaiser, Toxicol. Appl. Pharmacol. 6, 232 (1964); Fowler, Br. Vet. J. 127, 304 (1971). Comparative field trial in sheep: C. A. Hall et al., Res. Vet. Sci. 31, 104 (1981).
Properties: Light yellow, feathery crystals from glacial acetic acid, mp 157°. Freely sol in alcohol, very sparingly sol in water. LD50 in rats, mice (mg/kg): 170, 212 orally; 105, 88 i.v.; 105, 107 i.p.; 122, 110 s.c. (Kaiser).
Melting point: mp 157°
Toxicity data: LD50 in rats, mice (mg/kg): 170, 212 orally; 105, 88 i.v.; 105, 107 i.p.; 122, 110 s.c. (Kaiser)
Therap-Cat-Vet: Anthelmintic (hookworm).
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