Dopexamine

Title: Dopexamine
CAS Registry Number: 86197-47-9
CAS Name: 4-[2-[[6-[(2-Phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol
Additional Names: 4-[2-[[6-(phenethylamino)hexyl]amino]ethyl]pyrocatechol
Manufacturers' Codes: FPL-60278
Molecular Formula: C22H32N2O2
Molecular Weight: 356.50
Percent Composition: C 74.12%, H 9.05%, N 7.86%, O 8.98%
Literature References: Dopamine receptor and b2-adrenoreceptor agonist. Prepn: J. B. Farmer et al., EP 72061 (1983 to Fisons). Unlike dopamine, dopexamine has little or no activity at the a- and b1-adrenoceptors: R. A. Brown et al., Br. J. Pharmacol. 85, 599 (1985). Cardiovascular activity in dogs: eidem, ibid. 609. Hemodynamic effects in chronic congestive heart failure: J. R. Dawson et al., Br. Heart J. 54, 313 (1985); G. Svensson et al., Eur. Heart J. 7, 697 (1986). Human renovascular effects: F. Magrini et al., Eur. J. Clin. Pharmacol. 32, 1 (1987). Symposium on pharmacology and clinical efficacy: Am. J. Cardiol. 62, Suppl., 1C-88C (1988).
Derivative Type: Dihydrochloride
CAS Registry Number: 86484-91-5
Additional Names: Dopexamine hydrochloride
Manufacturers' Codes: FPL-60278AR
Trademarks: Dopacard (Medeus)
Molecular Formula: C22H32N2O2.2HCl
Molecular Weight: 429.42
Percent Composition: C 61.53%, H 7.98%, N 6.52%, O 7.45%, Cl 16.51%
Derivative Type: Dihydrobromide
Molecular Formula: C22H32N2O2.2HBr
Molecular Weight: 518.33
Percent Composition: C 50.98%, H 6.61%, N 5.40%, O 6.17%, Br 30.83%
Properties: Crystals from ethanol, mp 227-228°.
Melting point: mp 227-228°
Therap-Cat: Cardiotonic.
Keywords: ?Adrenergic Agonist; Cardiotonic; Dopamine Receptor Agonist.
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Dopexamine
Dopexamine.png
Systematic (IUPAC) name
4-[2-({6-[(2-phenylethyl)amino]hexyl}amino)ethyl]benzene-1,2-diol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Identifiers
CAS number 86197-47-9 YesY
ATC code C01CA14
PubChem CID 55483
ChemSpider 50102 YesY
UNII 398E7Z7JB5 YesY
KEGG D03891 YesY
ChEMBL CHEMBL77622 YesY
Chemical data
Formula C22H32N2O2 
Mol. mass 429.43 g/mol
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Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β1 and β2-adrenergic receptor agonist.[1] Its action at dopamine receptor D1 mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases noradrenaline release.[2]

Use in sepsis has been proposed.[3]

It is used as an inotropic agent in cardiac failure.[4] Side effects include arrhythmia, tremor, angina and flushing.