Dosmalfate

Title: Dosmalfate
CAS Registry Number: 122312-55-4
CAS Name: [m7-[7-[[6-O-[6-Deoxy-2,3,4-tri-O-(sulfo-kO)-a-L-mannopyranosyl]-2,3,4-tri-O-(sulfo-kO)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-[4-methoxy-3-[(sulfo-kO)oxy]pheny]-4H-1-benzopyran-4-onato(7-)]]tetradeca-m-hydroxyheneicosahydroxytetradecaaluminum
Additional Names: flavalfate
Manufacturers' Codes: F-3616
Trademarks: Diotul (FAES)
Molecular Formula: C28H60Al14O71S7
Molecular Weight: 2134.93
Percent Composition: C 15.75%, H 2.83%, Al 17.69%, O 53.21%, S 10.51%
Literature References: Diosmin, q.v., heptakis (hydrogen sulfate) aluminum complex. Prepn: A. Orjales-Venero, R. Mosquera-Pestana, EP 558435; eidem, US 5296469 (1993, 1994 both to FAES). In vivo protective effect in exptl colitis: I. Villegas et al., Eur. J. Pharmacol. 460, 209 (2003). Series of articles on pharmacology, toxicity and clinical studies as gastroprotectant and antiulcerative: Drugs Today 36 (Suppl. A), 25-85 (2000).
Properties: Yellow solid.
Therap-Cat: Gastroprotectant.
Keywords: Cytoprotectant (Gastric).
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