Dotarizine

Title: Dotarizine
CAS Registry Number: 84625-59-2
CAS Name: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Manufacturers' Codes: FI-6026
Molecular Formula: C29H34N2O2
Molecular Weight: 442.59
Percent Composition: C 78.70%, H 7.74%, N 6.33%, O 7.23%
Literature References: Mixed calcium channel blocker and serotonin (5-HT2) receptor antagonist. Prepn: R. Foguet et al., EP 97340; eidem, US 4883797 (1984, 1989 both to Ferrer); S. Gubert et al., Arzneim.-Forsch. 37, 1103 (1987). Clinical pharmacokinetics and tolerability: M. Farré et al., Methods Find. Exp. Clin. Pharmacol. 19, 343 (1997). Cerebrovascular study in goats: G. Torregrosa et al., Arzneim.-Forsch. 49, 668 (1999); in rabbits: N. Kuridze et al., J. Neurol. Sci. 175, 13 (2000). Mechanism of blockade: A. Ruiz-Nuno et al., Eur. J. Pharmacol. 411, 289 (2001).
Properties: White crystalline solid from methanol, mp 100-101° (Gubert); also reported as 93-97° (Foguet).
Melting point: mp 100-101° (Gubert); also reported as 93-97° (Foguet)
Therap-Cat: Antimigraine.
Keywords: Calcium Channel Blocker; Piperazine Derivatives; Serotonin Receptor Antagonist; Antimigraine.
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Dotarizine
Dotarizine.png
Systematic (IUPAC) name
1-[diphenylmethyl]-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Clinical data
Legal status  ?
Identifiers
CAS number 84625-59-2 YesY
ATC code None
PubChem CID 55285
UNII IO7663S6D3 N
Synonyms Dotarizine
Chemical data
Formula C29H34N2O2 
Mol. mass 442.592 g/mol
 N (what is this?)  (verify)

Dotarizine is a drug used in the treatment of migraine,[1] which acts as a calcium channel blocker,[2] and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors.[3][4] The anti-migraine action is thought to be due to its action as a vasodilator,[5][6] but it also has some anxiolytic effects[7] and blocks amnesia produced by electroconvulsive shock in animals.[8]