Doxacurium Chloride

Title: Doxacurium Chloride
CAS Registry Number: 106819-53-8
CAS Name: (1R,1¢S,2S,2¢R)-rel-2,2¢-[(1,4-Dioxo-1,4-butanediyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride
Additional Names: (1R,2S;1S,2R)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride succinate (2:1); trans,trans-2,2¢-[dimethylenebis(carbonyloxytrimethylene)]bis[1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium] dichloride
Manufacturers' Codes: BW-A938U
Trademarks: Nuromax (Glaxo Wellcome)
Molecular Formula: C56H78Cl2N2O16
Molecular Weight: 1106.13
Percent Composition: C 60.81%, H 7.11%, Cl 6.41%, N 2.53%, O 23.14%
Literature References: Benzylisoquinolinium, competitive neuromuscular blocker. Prepn: H. A. El-Sayad et al., EP 54309 (1982 to Wellcome Found.); eidem, US 4701460 (1987 to Burroughs Wellcome). Clinical pharmacology: S. J. Basta et al., Anesthesiology 69, 478 (1988). Clinical evaluation during anesthesia: R. P. F. Scott, J. Norman, Br. J. Anaesth. 62, 373 (1989).
Properties: Amorphous solid. Sol in water.
Therap-Cat: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents.
Doxapram Doxazosin Doxefazepam Doxenitoin Doxepin

Doxacurium chloride
Doxacurium chloride.svg
Systematic (IUPAC) name
bis[3-[6,7,8-trimethoxy-2-methyl-1- [(3,4,5-trimethoxyphenyl)methyl]- 3,4-dihydro-1H- isoquinolin-2-yl] propyl] butanedioate dichloride
Clinical data
Legal status Worldwide: prescription only medicine
Routes IV only
Pharmacokinetic data
Bioavailability 100% (IV)
Identifiers
CAS number 106819-53-8 YesY
ATC code M03AC07
PubChem CID 5284551
DrugBank DB01135
ChemSpider 4447606 YesY
UNII M78TVM3G5Z YesY
KEGG D00760 YesY
ChEBI CHEBI:59819 YesY
ChEMBL CHEMBL1200753 N
Chemical data
Formula C56H78Cl2N2O16 
Mol. mass 1106.13 g/mol
 N (what is this?)  (verify)

Doxacurium chloride (formerly recognized as BW938U80 or BW A938U[citation needed]) is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. Unlike a number of other related skeletal muscle relaxants, it is rarely used adjunctively to facilitate endotracheal intubation.