Doxofylline

Title: Doxofylline
CAS Registry Number: 69975-86-6
CAS Name: 7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(1,3-dioxolan-2-ylmethyl)theophylline; 2-(7¢-theophyllinemethyl)-1,3-dioxolane; doxophylline; dioxyfilline
Manufacturers' Codes: ABC-12/3
Trademarks: Ansimar (ABC); Maxivent; Ventax (Robert)
Molecular Formula: C11H14N4O4
Molecular Weight: 266.25
Percent Composition: C 49.62%, H 5.30%, N 21.04%, O 24.04%
Literature References: Prepn: U. Avico et al., Farmaco Ed. Sci. 17, 73 (1962). Use as bronchodilator: BE 868556; J. S. Franzone, T. Tamietto, US 4187308 (1978, 1980 to Istituto Biologico Chemioterapico ABC). Pharmacology: J. S. Franzone et al., Farmaco Ed. Sci. 36, 201 (1981). Pharmacodynamics and toxicity in rats: J. S. Franzone et al., ibid. 220. HPLC determn in pharmaceutical compositions: C. Badini et al., Farmaco Ed. Prat. 37, 320 (1982). Clinical trial in obstructive pneumopathy: C. Bucca et al., Int. J. Clin. Pharmacol. Res. 11, Suppl 1, 101 (1982).
Properties: Crystals, mp 144-145.5°. Sol in water, acetone, ethyl acetate, benzene, chloroform, dioxane, hot methanol or hot ethanol. Practically insol in ethyl ether or petr ether. LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone).
Melting point: mp 144-145.5°
Toxicity data: LD50 in mice (mg/kg): 841 orally; 215.6 i.v.; in rats: 1022.4 orally, 445 i.p. (Franzone)
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Xanthine Derivatives.
DPQ D-Psicose d-Quercitol Drazoxolon D-Ribose-5-phosphoric Acid

Doxofylline
Doxofylline.png
Systematic (IUPAC) name
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Clinical data
AHFS/Drugs.com International Drug Names
Legal status Prescription only
Routes Oral
Identifiers
CAS number 69975-86-6 YesY
ATC code R03DA11
PubChem CID 50942
UNII MPM23GMO7Z YesY
KEGG D03898 YesY
Chemical data
Formula C11H14N4O4 
Mol. mass 266.25 g/mol
 YesY (what is this?)  (verify)

Doxofylline (INN), (also known as doxophylline) is a xanthine derivative drug used in the treatment of asthma.[1]

It has antitussive[citation needed] and bronchodilator[2] effects, and acts as a phosphodiesterase inhibitor.[3]

In animal and human studies, it has shown similar efficacy to theophylline but with significantly fewer side effects.[4]

Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase.[1]