Title: Dyphylline
CAS Registry Number: 479-18-5
CAS Name: 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2,3-dihydroxypropyl)theophylline; (1,2-dihydroxy-3-propyl)theophylline; glyphylline; glyfyllin; diprophylline; AFI-phyllin
Trademarks: Astmamasit (Showa Yakuhin); Asthmolysin (Kade); Astrophyllin; Circair (Circle); Coronarin; Cor-Theophyllin (Paramedical); Dilor (Savage); Hiphyllin; Hyphylline; Lufyllin (Mallinckrodt); Neostenovasan; Neothylline (Lemmon); Neotilina; Neo-Vasophylline; Neutrafil; Neutraphylline (Dorsey); Prophyllen (Streuli); Silbephylline (Berk); Solufilin; Solufyllin; Theal ampules (Boehringer, Mann.); Thefylan
Molecular Formula: C10H14N4O4
Molecular Weight: 254.24
Percent Composition: C 47.24%, H 5.55%, N 22.04%, O 25.17%
Literature References: Prepn: Jones, Maney, US 2575344 (1951 to State Univ. of Iowa); Roth, Arch. Pharm. 292, 234 (1959). Toxicity data: R. A. Al'tshuler, Med. Prom. SSSR 16, 57 (1962), C.A. 61, 6230g (1964).
Properties: Extremely bitter crystals from alcohol, mp 158°. uv max (0.001% in H2O): 273 nm (A1%1cm 361). Freely sol in water; one gram dissolves in 3 ml H2O at 25°. Soly (g/100 ml): alc 2; chloroform 1. pH (1% aq soln) 6.6 to 7.3. LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler).
Melting point: mp 158°
Absorption maximum: uv max (0.001% in H2O): 273 nm (A1%1cm 361)
Toxicity data: LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler)
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Xanthine Derivatives.
Dypnone Dysidiolide Dystrophin Ebastine Ebimar?

Systematic (IUPAC) name
Clinical data
Trade names Lufyllin
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a682494
Pregnancy cat. C (US)
Legal status -only (US)
CAS number 479-18-5 YesY
ATC code R03DA01
PubChem CID 3182
DrugBank DB00651
ChemSpider 3070 YesY
UNII 263T0E9RR9 YesY
KEGG D00691 YesY
Synonyms 7-(2,3-dihydroxy-propyl)theophylline
Chemical data
Formula C10H14N4O4 
Mol. mass 254.24 g/mol
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Dyphylline (trade names Dilor, Lufyllin), also known as diprophylline, is a xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.[1][2]