Elgodipine

Title: Elgodipine
CAS Registry Number: 119413-55-7
CAS Name: 4-(1,3-Benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 2-[[(4-fluorophenyl)methyl]methylamino]ethyl 1-methylethyl ester
Additional Names: 2-[(p-fluorobenzyl)methylamino]ethyl isopropyl (±)- 1,4-dihydro-2,6-dimethyl-4-[2,3-(methylenedioxy)phenyl]-3,5-pyridinedicarboxylate
Molecular Formula: C29H33FN2O6
Molecular Weight: 524.58
Percent Composition: C 66.40%, H 6.34%, F 3.62%, N 5.34%, O 18.30%
Literature References: Dihydropyridine calcium channel blocker. Prepn: C. F. Torija, J. A. Galiano Ramos, EP 302980; eidem, US 4952592 (1989, 1990 both to Inst. Invest. Desarr. Quimicobiol.). In vitro and in vivo cardiovascular effects: J. Tamargo et al., Arzneim.-Forsch. 41, 895 (1991). Hemodynamic profile: C. Drieu la Rochelle et al., Br. J. Pharmacol. 111, 49 (1994). Clinical evaluation in coronary artery disease: H. Suryapranata et al., Am. J. Cardiol. 69, 1171 (1992). Clinical evaluation in chronic stable angina: D. U. Acharya et al., Eur. Heart J. 15, 665 (1994).
Derivative Type: Hydrochloride
CAS Registry Number: 121489-04-1
Manufacturers' Codes: IQB-875
Molecular Formula: C29H33FN2O6.HCl
Molecular Weight: 561.04
Percent Composition: C 62.08%, H 6.11%, F 3.39%, N 4.99%, O 17.11%, Cl 6.32%
Properties: Crystals from acetone, mp 194-195°. LD50 i.p. in mice: 30-40 mg/kg (Torija, Galiano Ramos).
Melting point: mp 194-195°
Toxicity data: LD50 i.p. in mice: 30-40 mg/kg (Torija, Galiano Ramos)
Therap-Cat: Antianginal.
Keywords: Antianginal; Calcium Channel Blocker; Dihydropyridine Derivatives.
Ellagic Acid Ellipticine Elliptinium Acetate Elliptone Eltoprazine