Endostatin

Title: Endostatin
CAS Registry Number: 187888-07-9
Literature References: Endogenous inhibitor of angiogenesis and tumor growth. mol wt ~20 kDa. C-terminal fragment of collagen XVIII, a collagen-like peptide localized around blood vessels. Released by the action of tumor-produced proteases on the collagen molecule. Isoln from murine hemangioendothelioma: M. S. O'Reilly et al., Cell 88, 277 (1997); from human plasma: L. Ständker et al., FEBS Lett. 420, 129 (1997). Crystal structure: E. Hohenester et al., EMBO J. 17, 1656 (1998). Antitumor activity in mice: T. Boehm et al., Nature 390, 404 (1997).
Endosulfan Endothall Endothelin Endralazine Endrin

Endostatin monomer, basic amino acid residues shown in red (source: pdb.org, 1KOE).

Endostatin is a naturally-occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.

Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).[1]