Enfenamic Acid

Title: Enfenamic Acid
CAS Registry Number: 23049-93-6
CAS Name: 2-[(2-Phenylethyl)amino]benzoic acid
Additional Names: N-phenethyl anthranilic acid
Manufacturers' Codes: RH-8
Trademarks: Tromaril (Unichem)
Molecular Formula: C15H15NO2
Molecular Weight: 241.29
Percent Composition: C 74.67%, H 6.27%, N 5.80%, O 13.26%
Literature References: Nonsteroidal anti-inflammatory, antipyretic, analgesic. Prepn: S. R. Hashim et al., IN 103066 and IN 114805 (both 1974 to Council Sci. Ind. Res.). Chemistry and pharmacology: P. Sisoda et al., Proc. Symp. CNS Drugs (Council of Scientific and Industrial Research, New Delhi, 1966) pp 238-248. Antithrombotic activity in rheumatoid arthritis and myocardial infarction: S. R. Manikeri et al., Indian J. Med. Res. 71, 438 (1980). Natriuretic activity: N. Kshirsagar et al., Br. J. Clin. Pharmacol. 9, 530 (1980). Clinical trial in nephrotic syndrome: eidem, Indian J. Med. Res. 70, 801 (1979); as postpartum analgesic: S. Tandon et al., Indian Med. Gaz. 116, 182 (1982).
Properties: Crystals, mp 116-117°. Insol in water. LD50 in mice (mg/kg): 575 i.p., >2000 orally (Sisoda).
Melting point: mp 116-117°
Toxicity data: LD50 in mice (mg/kg): 575 i.p., >2000 orally (Sisoda)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Aminoarylcarboxylic Acid Derivatives.
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