Enflurane

Title: Enflurane
CAS Registry Number: 13838-16-9
CAS Name: 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Additional Names: 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether; methylflurether
Manufacturers' Codes: compd 347; NSC-115944
Trademarks: Alyrane (Baxter); Efrane (Abbott); Ethrane (Baxter)
Molecular Formula: C3H2ClF5O
Molecular Weight: 184.49
Percent Composition: C 19.53%, H 1.09%, Cl 19.22%, F 51.49%, O 8.67%
Line Formula: CHF2OCF2CHClF
Literature References: Prepn by fluorination of the corresp dichloromethyl ether: R. C. Terrell, GB 1138406; idem, US 3469011; US 3527813 (1969, 1969, 1970 all to Air Reduction). Synthesis and anesthetic properties: R. C. Terrell et al., J. Med. Chem. 14, 517 (1971); 15, 604 (1972). Enantiomeric resolution: J. Meinwald et al., Science 251, 560 (1991).
Properties: Stable, volatile, non-flammable liq. bp 56.5°. nD20 1.3025. d2525 1.5167. Does not degrade in the presence of alkali or light. Miscible with other organic liquids incl. fats and oils.
Boiling point: bp 56.5°
Index of refraction: nD20 1.3025
Density: d2525 1.5167
CAUTION: Potential symptoms of overexposure are eye irritation; CNS depression, analgesia, anesthesia, seizures, respiratory depression. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 128.
Therap-Cat: Anesthetic (inhalation).
Keywords: Anesthetic (Inhalation).
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Enflurane
Enflurane.svg
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Systematic (IUPAC) name
(RS)-2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane
Clinical data
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Pharmacokinetic data
Protein binding 97%
Identifiers
CAS number 13838-16-9
ATC code N01AB04
PubChem CID 3226
DrugBank DB00228
ChemSpider 3113 YesY
UNII 91I69L5AY5 YesY
KEGG D00543 YesY
ChEBI CHEBI:4792
ChEMBL CHEMBL1257 YesY
Chemical data
Formula C3H2ClF5O 
Mol. mass 184.492 g/mol
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Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It is no longer in common use.

Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature. It is largely replacing halothane as a general anesthetic since 1980s.[1]