Eotaxin

Title: Eotaxin
Literature References: Chemoattractant protein that is highly selective for eosinophils. Member of the family of proinflammatory substances known as CC (or b-) chemokines. Purification and proposed role in allergic asthma: D. A. Griffiths-Johnson et al., Biochem. Biophys. Res. Commun. 197, 1167 (1993); P. J. Jose et al., J. Exp. Med. 179, 881 (1994). Cloning of guinea pig eotaxin: idem et al., Biochem. Biophys. Res. Commun. 205, 788 (1994); of human eotaxin: P. D. Ponath et al., J. Clin. Invest. 97, 604 (1996). Cloning of the eosinophil eotaxin receptor (CKR-3): B. L. Daugherty et al., J. Exp. Med. 183, 2349 (1996); P. D. Ponath et al., ibid. 2437. Discussion of role in allergic inflammation: H. Kita, G. J. Gleich, ibid. 2421-2426.
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The eotaxins are a CC chemokine subfamily of eosinophil chemotactic proteins.[1]

In humans, there are three family members:

  • CCL11 (eotaxin-1)
  • CCL24 (eotaxin-2)
  • CCL26 (eotaxin-3)