Erythrophleine

Title: Erythrophleine
CAS Registry Number: 36150-73-9
CAS Name: (1S,4aR,4bS,7E,8R,8aS,9S,10aR)-Tetradecahydro-9-hydroxy-1,4a,8-trimethyl-7-[2-[2-(methylamino)ethoxy]-2-oxoethylidene]-1-phenanthrenecarboxylic acid methyl ester
Additional Names: norcassamidine
Molecular Formula: C24H39NO5
Molecular Weight: 421.57
Percent Composition: C 68.38%, H 9.32%, N 3.32%, O 18.98%
Literature References: From the bark of Erythrophleum guineense G. Don., Leguminosae. Isoln: Harnack, Arch. Pharm. 234, 561 (1896). Structural studies: Blount et al., J. Chem. Soc. 1940, 286. Revised structure and identity with norcassamidine: Friedrich-Fiechtl, Spiteller, Ber. 104, 3538 (1971). Activity: Flacke, J. Pharmacol. Exp. Ther. 125, 49 (1959).
Properties: Solid from ethanol-ether, mp 115°. [a]D20 -22.5° (c = 0.65 in ethanol). Sol in water and alcohol.
Melting point: mp 115°
Optical Rotation: [a]D20 -22.5° (c = 0.65 in ethanol)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.
Status: This monograph has been retired and is no longer subject to revision or update.
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