Etamiphyllin

Title: Etamiphyllin
CAS Registry Number: 314-35-2
CAS Name: 7-[2-(Diethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2-diethylaminoethyl)theophylline; 7-(2-diethylaminoethyl)-1,3-dimethylxanthine; 1,3-dimethyl-7-(2-diethylaminoethyl)xanthine; dietamiphylline; etamiphylline
Molecular Formula: C13H21N5O2
Molecular Weight: 279.34
Percent Composition: C 55.90%, H 7.58%, N 25.07%, O 11.46%
Literature References: Prepn: Quevauviller et al., Bull. Soc. Chim. Biol. 31, 532 (1946); Moussalli et al., GB 669070 (1952); Klosa, Arch. Pharm. 288, 301 (1955). Toxicity data on combinations: Baettig, Arzneim.-Forsch. 21, 354 (1971). Pharmacokinetics, metabolism, and urinary determn in camels: M. Elghazali et al., J. Vet. Pharmacol. Ther. 25, 43 (2002); GC/MS and LC/MS determn in greyhound urine: M. C. Dumasia, P. Teale, J. Pharm. Biomed. Anal. 36, 1085 (2005).
Properties: Waxy solid, mp 75°. Very sol in water, acetone; slightly sol in ethanol, ether.
Melting point: mp 75°
Derivative Type: Hydrochloride
CAS Registry Number: 17140-68-0
Trademarks: Solufilina (Merck KGaA)
Molecular Formula: C13H21N5O2.HCl
Molecular Weight: 315.80
Percent Composition: C 49.44%, H 7.02%, N 22.18%, O 10.13%, Cl 11.23%
Properties: Crystals, mp 239-241°. Very sol in water, forms stable neutral soln.
Melting point: mp 239-241°
Derivative Type: Camphorsulfonate
CAS Registry Number: 19326-29-5
Additional Names: Etamiphylline camsylate
Trademarks: Millophyline (Arnolds)
Molecular Formula: C23H37N5O6S
Molecular Weight: 511.63
Percent Composition: C 53.99%, H 7.29%, N 13.69%, O 18.76%, S 6.27%
Properties: Crystals, mp 174°.
Melting point: mp 174°
Therap-Cat: Bronchodilator.
Therap-Cat-Vet: Bronchodilator.
Keywords: Bronchodilator; Xanthine Derivatives.
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