Ethosuximide

Title: Ethosuximide
CAS Registry Number: 77-67-8
CAS Name: 3-Ethyl-3-methyl-2,5-pyrrolidinedione
Additional Names: 2-ethyl-2-methylsuccinimide; a-ethyl-a-methylsuccinimide; 3-methyl-3-ethylpyrrolidine-2,5-dione
Trademarks: Atysmal (Schaefer); Capitus (Berk); Emeside (L.A.B.); Epileo Petitmal (Eisai); Ethymal; Mesentol; Pemal (Benzon); Peptinimid (Iromedica); Petinimid; Petnidan (Desitin); Pyknolepsinum (Rhein-Pharma); Simatin (Geistlich); Succimal (Clin-Comar-Byla); Suxilep; Suximal; Suxinutin (Parke-Davis); Zarontin (Parke-Davis)
Molecular Formula: C7H11NO2
Molecular Weight: 141.17
Percent Composition: C 59.56%, H 7.85%, N 9.92%, O 22.67%
Literature References: Prepn: Sircar, J. Chem. Soc. 1927, 1252. Acute toxicity data: H. Najer et al., Bull. Soc. Chim. Fr. 3, 1119 (1966). Comparative clinical trial with valproic acid in epilepsy: S. Sato et al., Neurology 32, 157 (1982). Brief review: S. J. Wallace, Neurol. Clin. 4, 601 (1986).
Properties: Crystals from acetone + ether, mp 64-65°. Freely sol in water. LD50 in mice (g/kg): 1.65 i.p.; 1.75 orally (Najer).
Melting point: mp 64-65°
Toxicity data: LD50 in mice (g/kg): 1.65 i.p.; 1.75 orally (Najer)
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.
Ethoxazene Ethoxyquin Ethoxysulfuron Ethoxzolamide Ethybenztropine

Ethosuximide
Systematic (IUPAC) name
(RS)-3-ethyl-3-methyl-pyrrolidine-2,5-dione
Clinical data
Trade names Zarontin
AHFS/Drugs.com monograph
MedlinePlus a682327
Pregnancy cat. D (Australia, United States)
Legal status ℞-only (U.S.)
Routes Oral
Pharmacokinetic data
Bioavailability 93%[1]
Metabolism Hepatic (CYP3A4, CYP2E1)
Half-life 53 hours
Excretion Renal (20%)
Identifiers
CAS number 77-67-8 YesY
ATC code N03AD01
PubChem CID 3291
DrugBank DB00593
ChemSpider 3175 YesY
UNII 5SEH9X1D1D YesY
KEGG D00539 YesY
ChEBI CHEBI:4887 YesY
ChEMBL CHEMBL696 YesY
Chemical data
Formula C7H11NO2 
Mol. mass 141.168 g/mol
 YesY (what is this?)  (verify)

Ethosuximide is a succinimide anticonvulsant, used mainly in absence seizures.