Ethyl Butylacetylaminopropionate

Title: Ethyl Butylacetylaminopropionate
CAS Registry Number: 52304-36-6
CAS Name: N-Acetyl-N-butyl-b-alanine ethyl ester
Additional Names: 3-(N-butyl-N-acetyl)-aminopropionic acid ethyl ester; ethyl-3-(N-n-butyl-N-acetyl)aminopropionate; insect repellent 3535
Trademarks: IR 3535 (Merck KGaA)
Molecular Formula: C11H21NO3
Molecular Weight: 215.29
Percent Composition: C 61.37%, H 9.83%, N 6.51%, O 22.29%
Literature References: N-Disubstituted derivative of b-alanine, q.v. Prepd (not claimed): M. Klier et al., DE 2246433; eidem, US 4127672 (1974, 1978 both to Beiersdorf). Prepn, toxicity and insect repellency studies: M. Klier, F. Kuhlow, J. Soc. Cosmetic Chem. 27, 141 (1976). Chemical, physical and toxicological properties: WHO Interim Specification for IR 3535 (WHO/IS/TC/667/2001) 15 pp. Lab and field tests of efficacy vs mosquitoes: U. Thavara et al., J. Am. Mosq. Control Assoc. 17, 190 (2001); and comparison to other repellents: D. R. Barnard et al., J. Med. Entomol. 39, 895 (2002); M. S. Fradin, J. F. Day, N. Engl. J. Med. 347, 13 (2002). HPLC determn in topical gel formulation: S. C. Marselos, H. A. Archontaki, J. Chromatogr. A 946, 295 (2002). Assessment of efficiency of repellent formulations: R. Milutinovic et al., SOFW-J. 128, 14 (2002). Review of repellency spectrum vs target pests: F. Marchio, ibid. 122, 478-485 (1996).
Properties: Colorless to slightly yellowish, almost odorless liquid. mp <-20°. bp0.2 108-110°. bp0.5 126-127°. nD20 1.452-1.455. Flash point: 318°F (159°C). Log P (octanol/water): 1.7 (23°). Vapor pressure at 20°: 0.15 Pa. Soly at 20°: water 70 ±3 g/l (non-buffered). Sol in n-heptane, dichloromethane, ethyl acetate, p-xylene, acetone, methanol. LD50 in rats (mg/kg): >5000 orally; LC50 in rats (mg/l): >5.1 by inhalation (WHO).
Melting point: mp <-20°
Boiling point: bp0.2 108-110°; bp0.5 126-127°
Flash point: Flash point: 318°F (159°C)
Index of refraction: nD20 1.452-1.455
Log P: Log P (octanol/water): 1.7 (23°)
Toxicity data: LD50 in rats (mg/kg): >5000 orally; LC50 in rats (mg/l): >5.1 by inhalation (WHO)
Use: Insect repellent.
Ethyl Butyrate Ethyl Caprate Ethyl Caproate Ethyl Caprylate Ethyl Carbonate