Etiroxate

Title: Etiroxate
CAS Registry Number: 17365-01-4
CAS Name: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-a-methyl-DL-tyrosine ethyl ester
Additional Names: DL-a-methylthyroxine ethyl ester
Manufacturers' Codes: CG-635
Molecular Formula: C18H17I4NO4
Molecular Weight: 818.95
Percent Composition: C 26.40%, H 2.09%, I 61.98%, N 1.71%, O 7.81%
Literature References: Deriv of thyroxine, q.v. Prepn: NL 6614150; H. Kummer, R. Beckmann, US 3930017 (1967, 1975 both to Grünenthal). Animal studies: R. Beckmann, Arzneim.-Forsch. 29, 499 (1979). Effect on iodine metabolism in man: D. Emrich, ibid. 27, 422 (1977). Use in hyperlipoproteinemia: H. Banz, F. P. Gall, Fortschr. Med. 97, 1942 (1979); eidem, Med. Klin. 75, 51 (1980).
Properties: Cryst from ethanol, mp 156-157°.
Melting point: mp 156-157°
Derivative Type: Hydrochloride
CAS Registry Number: 55327-22-5
Trademarks: Skleronorm (Grenthal)
Molecular Formula: C18H17I4NO4.HCl
Molecular Weight: 855.41
Percent Composition: C 25.27%, H 2.12%, I 59.34%, N 1.64%, O 7.48%, Cl 4.14%
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Thyroid Hormones/Analogs.
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