Etizolam

Title: Etizolam
CAS Registry Number: 40054-69-1
CAS Name: 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Additional Names: 1-methyl-6-o-chlorophenyl-8-ethyl-4H-s-triazolo[3,4-c]thieno[2,3-e]-1,4-diazepine
Manufacturers' Codes: Y-7131
Trademarks: Depas (Yoshitomi)
Molecular Formula: C17H15ClN4S
Molecular Weight: 342.85
Percent Composition: C 59.55%, H 4.41%, Cl 10.34%, N 16.34%, S 9.35%
Literature References: Prepn: M. Nakanishi et al., DE 2229845; eidem, US 3904641 (1972, 1973 both to Yoshitomi). Pharmacology and toxicity studies: T. Tsumagari et al., Arzneim.-Forsch. 28, 1158 (1978). Effect on monoamine metabolism in brain: M. Setoguchi et al., ibid. 1165; on rage responses in cats: T. Fukuda, T. Tsumagari, Jpn. J. Pharmacol. 33, 885 (1983).
Properties: Crystals from toluene, mp 147-148°. LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari).
Melting point: mp 147-148°
Toxicity data: LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari)
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.
Etodroxizine Etofenamate Etofenprox Etofibrate Etofylline

Etizolam
Etizolam.svg
Etizolam3d.png
Systematic (IUPAC) name
7-(2-Chlorophenyl)-4-ethyl-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,6] trideca-2(6),4,7,10,12-pentaene
Clinical data
Trade names Etilaam
Pregnancy cat. N
Legal status Unscheduled (UK) Unscheduled (US)
Routes Oral, Sublingual
Pharmacokinetic data
Bioavailability 93%
Metabolism Hepatic
Half-life 3.4 hours

(main metabolite is 8.2 hours)

Excretion Renal
Identifiers
CAS number 40054-69-1 YesY
ATC code N05BA19
PubChem CID 3307
ChemSpider 3191 YesY
UNII A76XI0HL37 YesY
KEGG D01514 YesY
ChEMBL CHEMBL1289779 N
Chemical data
Formula C17H15ClN4S 
Mol. mass 342.07
 N (what is this?)  (verify)

Etizolam (marketed under the brand name Etilaam, Etizest, Etizola, Sedekopan, Pasaden or Depas) is a benzodiazepine analog.[1] The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring, making the drug a thienodiazepine.[2] It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.[3]