Factor VII

Title: Factor VII
CAS Registry Number: 9001-25-6
CAS Name: Blood-coagulation factor VII
Additional Names: proconvertin; co-thromboplastin; serum prothrombin conversion accelerator; SPCA
Literature References: Enzyme which, in conjunction with tissue factor and Ca2+ ions initiates the activation of factor X, q.v. Isoln from human plasma or serum: Fantt, Osborn, Thromb. Diath. Haemorrh. 8, 286 (1962); from bovine plasma: J. Jesty, Y. Nemerson, J. Biol. Chem. 249, 509 (1974). Separation from factor X by DEAE cellulose: Hougie, Bunting, in New Blood Clotting Factors, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1960) pp 40-42. Purification and structure of bovine factor VII: J. Jesty, Y. Nemerson, J. Biol. Chem. 249, 509 (1974); R. Radcliffe, Y. Nemerson, ibid. 250, 388 (1975); eidem, Methods Enzymol. 45B, 49 (1976). Its deficiency results in retarded prothrombin conversion and an elevated one-stage prothrombin time: Alexander in Thrombolytic Activity and Related Phenomena, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1961) pp 392-402. Factor VII deficiency is associated with severe liver disease, vitamin K deficiency and broad spectrum antibiotic therapy, or may follow anticoagulant coumarin therapy.
Factor VIII Factor X Factor XI Factor XII Factor XIII

Coagulation factor VII (serum prothrombin conversion accelerator)

Anchoring of coagulation factor VIIa (PDB 1dan[1]) to the membrane through its Gla domain
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols F7 (; SPCA)
External IDs OMIM: 613878 MGI: 109325 HomoloGene: 7710 ChEMBL: 3991 GeneCards: F7 Gene
EC number 3.4.21.21
RNA expression pattern
PBB GE F7 207300 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2155 14068
Ensembl ENSG00000057593 ENSMUSG00000031443
UniProt P08709 P70375
RefSeq (mRNA) NM_000131 NM_010172
RefSeq (protein) NP_000122 NP_034302
Location (UCSC) Chr 13:
113.76 – 113.77 Mb
Chr 8:
13.03 – 13.04 Mb
PubMed search [1] [2]

Factor VII (EC 3.4.21.21, blood-coagulation factor VIIa, activated blood coagulation factor VII, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. A recombinant form of human factor VIIa (NovoSeven, eptacog alfa [activated]) has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients. It is sometimes used unlicensed in severe uncontrollable bleeding, although there have been safety concerns. A Biosimilar form of recombinant activated factor VII (AryoSeven) is also available, but does not play any considerable role in the market.