|Factor VIII||Factor X||Factor XI||Factor XII||Factor XIII|
|Coagulation factor VII (serum prothrombin conversion accelerator)|
Anchoring of coagulation factor VIIa (PDB ) to the membrane through its Gla domain
|Symbols||F7 (; SPCA)|
|External IDs||ChEMBL: GeneCards:|
|RNA expression pattern|
Factor VII (EC 18.104.22.168, blood-coagulation factor VIIa, activated blood coagulation factor VII, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. A recombinant form of human factor VIIa (NovoSeven, eptacog alfa [activated]) has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients. It is sometimes used unlicensed in severe uncontrollable bleeding, although there have been safety concerns. A Biosimilar form of recombinant activated factor VII (AryoSeven) is also available, but does not play any considerable role in the market.