Factor X

Title: Factor X
CAS Registry Number: 9001-29-0
CAS Name: Blood-coagulation factor X
Additional Names: Stuart-Prower factor; Stuart factor; Prower factor
Literature References: Enzyme which is activated by a complex of factors IX, VIII, calcium ions and phospholipid, or by factor VII and tissue factor in the intrinsic and extrinsic pathways of blood coagulation resp. Non-physiological activators are trypsin and a specific protein from Russel's viper venom: see Fujikawa et al., Biochemistry 11, 4892 (1972). Active factor X apparently acts upon factor V, q.v. in the presence of calcium ions and lipid to form a complex which activates the conversion of prothrombin to thrombin. Present in both plasma and serum because neither increases nor decreases during clotting. Presumably synthesized in the liver because level is reduced with coumarin drugs and in liver disease. Isoln and characterization of bovine factor X: eidem., ibid. 4882. Factor Xa is a serine protease which, in the presence of factor V, Ca2+ ions and phospholipids, activates prothrombin. Severe deficiency causes hemorrhagic state resembling hemophilia. Mild deficiency may result in easy bruising. In severe cases deep muscular and joint hemorrhages occur. Improved purification and bibliography of earlier isoln procedures: Bajaj, Mann, J. Biol. Chem. 248, 7729 (1973). Comparison of the molecular forms generated by the different methods of activation: Radcliffe, Barton, ibid. 6788. Review: Graham, Hougie in Thombolytic Activity and Related Phenomena, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1961) pp 416-420; C. M. Jackson, Thromb. Diath. Haemorrh. Suppl. 57, 197-216 (1974). Reviews on prepn, physical properties and function in the coagulation process: K. Fujikawa, E. W. Davie, Methods Enzymol. 45B, 89 (1976); J. Jesty, Y. Nemerson, ibid. p 95.
Properties: Stable at room temperature for several days. Adsorbed by BaSO4, Al(OH)3, Ca3(PO4)2, Seitz filters, bentonite and DEAE cellulose. At 56° is destroyed rapidly, in serum, less rapidly as citrate eluate. At 65° is destroyed rapidly in any form. Stable between pH 6.1-9.0. Soluble in water. Precipitates from water between pH 8-4. Isoelec pt pH 4.3.
Factor XI Factor XII Factor XIII Fadrozole Fagarine

Coagulation factor X

PDB rendering based on 1c5m.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols F10 (; FX; FXA)
External IDs OMIM: 613872 MGI: 103107 HomoloGene: 30976 ChEMBL: 244 GeneCards: F10 Gene
EC number 3.4.21.6
RNA expression pattern
PBB GE F10 205620 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2159 14058
Ensembl ENSG00000126218 ENSMUSG00000031444
UniProt P00742 O88947
RefSeq (mRNA) NM_000504 NM_001242368
RefSeq (protein) NP_000495 NP_001229297
Location (UCSC) Chr 13:
113.78 – 113.8 Mb
Chr 8:
13.04 – 13.06 Mb
PubMed search [1] [2]

Factor X, also known by the eponym Stuart-Prower factor or as prothrombinase, is an enzyme (EC 3.4.21.6) of the coagulation cascade. It is a serine endopeptidase (protease group S1).