Factor XI

Title: Factor XI
CAS Registry Number: 9013-55-2
CAS Name: Blood-coagulation factor XI
Additional Names: PTA; plasma thromboplastin antecedent
Literature References: Participates in the initial phases of blood coagulation. In normal plasma, factor XI is present in a precursor form and is converted to an active form, factor XIa, which in turn activates factor IX to factor IXa in the presence of Ca2+ ions: Ratnoff, Davie, Biochemistry 1, 677 (1962); Schiffman et al., Blood 22, 733 (1963); K. Fujikawa et al., Biochemistry 13, 4508 (1974). Deficiency is characterized by the moderate bleeding symptoms of hemophilia C; by pathological clotting and recalcification times, impaired prothrombin consumption, and delayed thromboplastin formation: Duckert, Soulier in New Blood Clotting Factors, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1960) pp 145-147, 123-131. Review on bovine factor XI: T. Koide, Methods Enzymol. 45B, 65-73 (1976).
Factor XII Factor XIII Fadrozole Fagarine Famoxadone

Coagulation factor XI

PDB rendering based on 1xx9.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols F11 (; FXI)
External IDs OMIM: 264900 MGI: 99481 HomoloGene: 86654 ChEMBL: 2820 GeneCards: F11 Gene
EC number 3.4.21.27
RNA expression pattern
PBB GE F11 206610 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2160 109821
Ensembl ENSG00000088926 ENSMUSG00000031645
UniProt P03951 Q91Y47
RefSeq (mRNA) NM_000128 NM_028066
RefSeq (protein) NP_000119 NP_082342
Location (UCSC) Chr 4:
187.19 – 187.21 Mb
Chr 8:
45.24 – 45.26 Mb
PubMed search [1] [2]

Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene.[1][2][3][4]