Febuprol

Title: Febuprol
CAS Registry Number: 3102-00-9
CAS Name: 1-Butoxy-3-phenoxy-2-propanol
Manufacturers' Codes: H-33; K-10033
Trademarks: Valbil (Procter & Gamble)
Molecular Formula: C13H20O3
Molecular Weight: 224.30
Percent Composition: C 69.61%, H 8.99%, O 21.40%
Literature References: Prepn: W. F. Minor et al., J. Am. Chem. Soc. 76, 2993 (1954). Prepn and use as choleretic: H. Hoffmann et al., DE 2120396; eidem, US 3839587 (1972, 1974 both to Klinge). Pharmacology: G. Hofrichter et al., Arzneim.-Forsch. 24, 111 (1974). Pharmacokinetics, metabolism: K. Rehm et al., ibid. 26, 813 (1976). Spasmolytic action: R. Eisenburger, ibid. 27, 1429 (1977). Clinical studies: C. Wolf et al., Muench. Med. Wochenschr. 118, 1285 (1976); W. E. Scholing, W. Weinert, ibid. 120, 143 (1978); U. Ritter, H. J. Kyrein, Arzneim.-Forsch. 33, 891 (1983).
Properties: Colorless oil, bp11 165°; bp1.0 125-132°. nD20 1.5004. d420 1.027. LD50 in mice, rats (mg/kg): 3050, 2370 orally; 436, 400 i.p. (Hofrichter).
Boiling point: bp11 165°; bp1.0 125-132°
Index of refraction: nD20 1.5004
Density: d420 1.027
Toxicity data: LD50 in mice, rats (mg/kg): 3050, 2370 orally; 436, 400 i.p. (Hofrichter)
Therap-Cat: Choleretic.
Keywords: Choleretic.
Feclemine Fedotozine Felbamate Felbinac Felinine