Title: Felbamate
CAS Registry Number: 25451-15-4
CAS Name: 2-Phenyl-1,3-propanediol dicarbamate
Additional Names: carbamic acid 2-phenyltrimethylene ester
Manufacturers' Codes: ADD-03055; W-554
Trademarks: Felbamyl (Wallace); Felbatol (Carter-Wallace); Taloxa (Schering-Plough)
Molecular Formula: C11H14N2O4
Molecular Weight: 238.24
Percent Composition: C 55.46%, H 5.92%, N 11.76%, O 26.86%
Literature References: Antiepileptic, structurally similar to meprobamate, q.v. Prepn: F. M. Berger, B. J. Ludwig, US 2884444 (1959 to Carter); B. J. Ludwig et al., J. Med. Chem. 12, 462 (1969). Use in treatment of epileptic seizures: R. D. Sofia, US 4978680 (1990 to Carter-Walace). HPLC determn in plasma: R. P. Remmel et al., Ther. Drug Monit. 12, 90 (1990). Pharmacology: E. A. Swinyard et al., Epilepsia 27, 27 (1986). Metabolism in animals: J. T. Yang et al., Drug Metab. Dispos. 19, 1126 (1991). Penetration of blood brain barrier: E. M. Cornford et al., Epilepsia 33, 944 (1992). Clinical pharmacokinetics: A. J. Wilensky et al., ibid. 26, 602 (1985). Clinical trial in refractory partial seizures: E. Faught et al., Neurology 43, 688 (1993). Efficacy in childhood epileptic encephalopathy (Lennox-Gastaut syndrome): F. J. Ritter et al., N. Engl. J. Med. 328, 29 (1993). Review of pharmacology, toxicology and clinical evaluation: R. D. Sofia et al., Epilepsy Res. Suppl. 3, 103-108 (1991).
Properties: White, odorless powder, mp 151-152°. Sparingly sol in water, methanol, ethanol, acetone and chloroform; freely sol in DMSO, 1-methyl-2-pyrrolidinone and DMF. LD50 i.p. in mice: 4000 mg/kg (Ludwig et al.).
Melting point: mp 151-152°
Toxicity data: LD50 i.p. in mice: 4000 mg/kg (Ludwig et al.)
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.
Felbinac Felinine Felodipine Fenadiazole Fenalamide

Systematic (IUPAC) name
(3-carbamoyloxy-2-phenylpropyl) carbamate
Clinical data
Trade names Felbatol
AHFS/Drugs.com monograph
MedlinePlus a606011
Pregnancy cat. C (USA)
Legal status Unscheduled
Routes Oral
Pharmacokinetic data
Bioavailability > 90%
Metabolism Hepatic
Half-life 20-23 hours
Excretion  ?
CAS number 25451-15-4 YesY
ATC code N03AX10
PubChem CID 3331
DrugBank DB00949
ChemSpider 3214 YesY
KEGG D00536 YesY
Chemical data
Formula C11H14N2O4 
Mol. mass 238.24
 YesY (what is this?)  (verify)

Felbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug [1] used in the treatment of epilepsy. It is used to treat partial seizures [2][3] (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy.