Fendosal

Title: Fendosal
CAS Registry Number: 53597-27-6
CAS Name: 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-2-hydroxybenzoic acid
Additional Names: 5-(4,5-dihydro-2-phenyl-3H-benz[e]indol-3-yl)salicylic acid; 3-(3-carboxy-4-hydroxyphenyl)-2-phenyl-4,5-dihydro-3H-benz[e]indole
Manufacturers' Codes: HP-129; P-71-0129
Trademarks: Alnovin (Hoechst)
Molecular Formula: C25H19NO3
Molecular Weight: 381.42
Percent Composition: C 78.72%, H 5.02%, N 3.67%, O 12.58%
Literature References: Prepn: R. C. Allen, B. Anderson, DE 2407671; eidem, US 3878225 (1974, 1975 both to Hoechst); V. B. Anderson et al., J. Med. Chem. 19, 318 (1976). Pharmacology: H. B. Lassman et al., Agents Actions 8, 209 (1978). Clinical study: S. S. Bloomfield et al., Clin. Pharmacol. Ther. 23, 390 (1978).
Properties: Crystals from acetic acid, mp 223-225° (dec). LD50 in mice, rats, rabbits (mg/kg): 740, 450, 560 orally; in mice (mg/kg): 510 i.p. (Lassman).
Melting point: mp 223-225° (dec)
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): 740, 450, 560 orally; in mice (mg/kg): 510 i.p. (Lassman)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives.
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