Fenethazine

Title: Fenethazine
CAS Registry Number: 522-24-7
CAS Name: N,N-Dimethyl-10H-phenothiazine-10-ethanamine
Additional Names: 10-(b-dimethylaminoethyl)phenothiazine
Manufacturers' Codes: RP-3015; SC-1627
Trademarks: Anergan; Anergen; Ethysine; Etisine; Lisergan; Lysergan; Phenethazinum; Rutergan
Molecular Formula: C16H18N2S
Molecular Weight: 270.39
Percent Composition: C 71.07%, H 6.71%, N 10.36%, S 11.86%
Literature References: Prepd by the condensation of phenothiazine with dimethylaminoethyl chloride: Charpentier, US 2519886 (1950 to Rhône-Poulenc). Pharmacology: C. A. Winter, J. Pharmacol. Exp. Ther. 90, 224 (1947); A. von Schlichtegroll, Arzneim.-Forsch. 8, 489 (1958).
Properties: bp1 183-187°.
Boiling point: bp1 183-187°
Derivative Type: Hydrochloride
CAS Registry Number: 5934-20-3
Molecular Formula: C16H18N2S.HCl
Molecular Weight: 306.85
Percent Composition: C 62.63%, H 6.24%, N 9.13%, S 10.45%, Cl 11.55%
Properties: mp 201-201.5°. LD50 i.p. in mice: 140 ±13 mg/kg (Winter). LD50 orally in mice: 364 ±30 mg/kg (von Schlichtegroll).
Melting point: mp 201-201.5°
Toxicity data: LD50 i.p. in mice: 140 ±13 mg/kg (Winter); LD50 orally in mice: 364 ±30 mg/kg (von Schlichtegroll)
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Tricyclics; Phenothiazines.
Status: This monograph has been retired and is no longer subject to revision or update.
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