Title: Fenoldopam
CAS Registry Number: 67227-56-9
CAS Name: 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol
Additional Names: 6-chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
Manufacturers' Codes: SKF-82526
Molecular Formula: C16H16ClNO3
Molecular Weight: 305.76
Percent Composition: C 62.85%, H 5.27%, Cl 11.60%, N 4.58%, O 15.70%
Literature References: Dopamine D1-receptor agonist. Prepn: J. Weinstock, DE 2751258; idem, US 4197297 (1978, 1980 both to SmithKline); J. Weinstock et al., J. Med. Chem. 23, 973 (1980). HPLC determn in urine and plasma: V. K. Boppana et al., J. Chromatogr. 317, 463 (1984). Clinical pharmacology: R. M. Stote et al., Clin. Pharmacol. Ther. 34, 309 (1983); R. M. Carey et al., J. Clin. Invest. 74, 2198 (1984). Hemodynamic effects in hypertension: H. O. Ventura et al., Circulation 69, 1142 (1984); M. P. Caruana et al., Br. J. Clin. Pharmacol. 24, 721 (1987). Clinical evaluation in congestive heart failure: G. S. Francis et al., Am. Heart J. 116, 473 (1988).
Derivative Type: Hydrobromide
Molecular Formula: C16H16ClNO3.HBr
Molecular Weight: 386.67
Percent Composition: C 49.70%, H 4.43%, Cl 9.17%, N 3.62%, O 12.41%, Br 20.66%
Properties: mp 277° (dec).
Melting point: mp 277° (dec)
Derivative Type: Methanesulfonate
CAS Registry Number: 67227-57-0
Additional Names: Fenoldopam mesylate
Manufacturers' Codes: SKF-82526-J
Trademarks: Corlopam (SKB)
Molecular Formula: C16H16ClNO3.CH3SO3H
Molecular Weight: 401.86
Percent Composition: C 50.81%, H 5.02%, Cl 8.82%, N 3.49%, O 23.89%, S 7.98%
Properties: mp 274° (dec).
Melting point: mp 274° (dec)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dopamine Receptor Agonist.
Fenoprofen Fenoterol Fenoverine Fenoxanil Fenoxaprop-ethyl

Fenoldopam 3d balls.png
Systematic (IUPAC) name
Clinical data
Trade names Corlopam
AHFS/Drugs.com monograph
Pregnancy cat. B (US)
Legal status -only (US)
Routes IV
Pharmacokinetic data
Metabolism Hepatic (CYP not involved)
Half-life 5 minutes
Excretion Renal (90%) and fecal (10%)
CAS number 67227-57-0 YesY
ATC code C01CA19
PubChem CID 3341
IUPHAR ligand 939
DrugBank DB00800
ChemSpider 3224 YesY
KEGG D07946 YesY
Chemical data
Formula C16H16ClNO3 
Mol. mass 305.76 g/mol
 YesY (what is this?)  (verify)

Fenoldopam mesylate (Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.[1] Fenoldopam is used as an antihypertensive agent.[2] It was approved by the Food and Drug Administration (FDA) in September 1997.[3]