|Fibrin||Fibroblast Growth Factor||Fibrolase||Fibronectins||Fichtelite|
|Systematic (IUPAC) name|
|Mol. mass||372.09 g/mol|
|(what is this?)|
Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue. It was originally designed as a therapy for hepatitis B virus infection. In a 1992 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from fulminant liver failure associated with lactic acidosis. This toxicity was unusual in that it was not predicted by animal studies. It is suspected that the drug induced mitochondrial damage, as hinted by in-vitro studies.