Firocoxib

Title: Firocoxib
CAS Registry Number: 189954-96-9
CAS Name: 3-(Cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
Manufacturers' Codes: ML-1785713
Trademarks: Previcox (Merial)
Molecular Formula: C17H20O5S
Molecular Weight: 336.40
Percent Composition: C 60.70%, H 5.99%, O 23.78%, S 9.53%
Literature References: Selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: M. Belley et al., WO 9714691; eidem US 5981576 (1997, 1999 both to Merck Frosst). Pharmacokinetics and therapeutic efficacy in inflammatory synovitis in dogs: M. E. McCann et al., Am. J. Vet. Res. 65, 503 (2004).
Therap-Cat-Vet: Anti-inflammatory; analgesic.
Fisetin FITC Flavaspidic Acid Flavine-Adenine Dinucleotide Flavopereirine

Firocoxib
Firocoxib.svg
Firocoxib molecule
Systematic (IUPAC) name
3-(Cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
Clinical data
Trade names Equioxx; Previcox
AHFS/Drugs.com International Drug Names
Legal status Prescription Only (S4) (AU) POM (UK) -only (US) Veterinary use only
Routes Oral
Identifiers
CAS number 189954-96-9
ATCvet code QM01AH90
PubChem CID 208910
ChemSpider 181008 YesY
UNII Y6V2W4S4WT YesY
KEGG D03712 YesY
ChEBI CHEBI:76136
ChEMBL CHEMBL69998 YesY
Chemical data
Formula C17H20O5S 
Mol. mass 336.402 g/mol
 YesY (what is this?)  (verify)

Firocoxib (INN; brand names Equioxx and Previcox) is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, currently approved for use in dogs and horses. Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses.[1] Firocoxib is not intended or approved for use in human medicine.[2]