Fisetin

Title: Fisetin
CAS Registry Number: 528-48-3
CAS Name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
Additional Names: 3,3¢,4¢,7-tetrahydroxyflavone; 5-desoxyquercetin; fisidenolon 1521; C.I. 75620; C.I. Natural Brown 1
Molecular Formula: C15H10O6
Molecular Weight: 286.24
Percent Composition: C 62.94%, H 3.52%, O 33.54%
Literature References: Flavanoid present in the bark and stems of a variety of trees. Isolation from Rhus cotinus L. Anacardiaceae, Venetian Sumach: Chevreul, Lecons Chim. Appl. a la Teint. 2, 169 (1833) [cf. J. Schmid, Ber. 19, 1734 (1886)]; from heartwood of Acacia spp, Leguminosae: Roux et al., Biochem. J. 78, 834 (1961). Structure: Seshadri, Annu. Rev. Biochem. 20, 492 (1951). Synthesis: St. Kostanecki et al., Ber. 37, 784 (1904); J. Allan, R. Robinson, J. Chem. Soc. 129, 2334 (1926). Inhibition of aflatoxin cytotoxicity: A. G. Schwartz, W. R. Rate, J. Environ. Pathol. Toxicol. 2, 1021 (1979). Mutagenicity studies: J. P. Brown et al., Biochem. Soc. Trans. 5, 1489 (1977); idem, P. S. Dietrich, Mutat. Res. 66, 223 (1979). TLC determn: D. Heimler, J. Chromatogr. 366, 407 (1986).
Properties: Yellow needles from dil alc, dec 330°. uv max (ethanol): 252, 320, 360 nm (log E1%1cm 2.62, 2.51, 2.73). Sol in alcohol, acetone, acetic acid, solns of fixed alkali hydroxides. Practically insol in water, ether, benzene, chloroform and petr ether.
Absorption maximum: uv max (ethanol): 252, 320, 360 nm (log E1%1cm 2.62, 2.51, 2.73)
FITC Flavaspidic Acid Flavine-Adenine Dinucleotide Flavopereirine Flavopiridol

Fisetin
Fisetin structure
Identifiers
CAS number 528-48-3 YesY
PubChem 5281614
ChemSpider 4444933 YesY
DrugBank DB07795
KEGG C10041 YesY
ChEBI CHEBI:42567 YesY
ChEMBL CHEMBL31574 YesY
Jmol-3D images Image 1
Properties
Molecular formula C15H10O6
Molar mass 286.2363 g/mol
Density 1.688 g/mL
Melting point 330 °C
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Its chemical formula was first described by Austrian chemist Josef Herzig in 1891.[1] Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation.