Flocoumafen

Title: Flocoumafen
CAS Registry Number: 90035-08-8
CAS Name: 4-Hydroxy-3-[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1-naphthalenyl]-2H-1-benzopyran-2-one
Additional Names: 4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1-naphthyl]
Manufacturers' Codes: WL-108366
Trademarks: Storm (BASF)
Molecular Formula: C33H25F3O4
Molecular Weight: 542.54
Percent Composition: C 73.06%, H 4.64%, F 10.51%, O 11.80%
Literature References: Second generation anticoagulant rodenticide. Prepn: I. D. Entwistle, P. Boehm, EP 98629; eidem, US 4520007 (1983, 1985 both to Shell). Synthesis and separation of isomers: O. S. Park, B. S. Jang, Arch. Pharmacal Res. 18, 277 (1995). HPLC determn in liver tissue: A. Jones, Bull. Environ. Contam. Toxicol. 56, 8 (1996). Absorption and distribution in rats: K. R. Huckle et al., Pestic. Sci. 25, 297 (1989). Efficacy against seven rodent species: J. E. Gill, Int. Biodeterior. Biodegrad. 30, 65 (1992). Review of physical properties, mode of action, and field trials: D. J. Bowler et al., Proc. Br. Crop Prot. Conf. - Pests Dis. 1984, 397.
Properties: White powder. Soly in water: 1.1 mg/l. Soly in acetone, alcohol, chloroform, dichloromethane: >10 g/l. Vapor pressure at 25°: approx 1 ´ 10-13 mm Hg. LD50 in rats, mice, rabbits (mg/kg): 0.25, 0.8, 0.2 orally (Bowler).
Toxicity data: LD50 in rats, mice, rabbits (mg/kg): 0.25, 0.8, 0.2 orally (Bowler)
Use: Rodenticide.
Floctafenine Flomoxef Flonicamid Flopropione Florantyrone

Flocoumafen
Flocoumafen.png
Identifiers
CAS number 90035-08-8 YesY
PubChem 91748
KEGG C18696 YesY
Jmol-3D images Image 1
Properties
Molecular formula C33H25F3O4
Molar mass 542.54441
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Flocoumafen is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a second generation (i.e., high potency) chemical in this class, used commercially as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the UK). This restriction is mainly due to the increased risk to non-target species, especially due to its tendency to bio-accumulate in exposed organisms. Studies have shown that rodents resistant to first generation anticoagulants, can be adequately controlled with Flocoumafen.