Florantyrone

Title: Florantyrone
CAS Registry Number: 519-95-9
CAS Name: g-Oxo-8-fluoranthenebutanoic acid
Additional Names: b-(8-fluoranthoyl)propionic acid
Trademarks: Zanchol (Searle)
Molecular Formula: C20H14O3
Molecular Weight: 302.32
Percent Composition: C 79.46%, H 4.67%, O 15.88%
Literature References: Prepn: R. R. Burtner, US 2773091 (1956 to Searle). See also: O. E. Fancher, US 2560425 (1951 to Miles Labs).
Properties: Lemon yellow crystals from acetic acid, mp ~208°. Soluble in methanol, ethanol, aq solns of sodium carbonate.
Melting point: mp ~208°
Therap-Cat: Choleretic.
Keywords: Choleretic.
Florasulam Floredil Florfenicol Flosequinan Floxacillin

Florantyrone
Florantyrone.png
Systematic (IUPAC) name
4-fluoranthen-8-yl-4-oxobutanoic acid
Clinical data
Legal status  ?
Identifiers
CAS number 519-95-9 YesY
ATC code None
PubChem CID 10617
UNII UZ5LMI200P YesY
Chemical data
Formula C20H14O3 
Mol. mass 302.323 g/mol
Physical data
Melt. point 195 °C (383 °F)
Solubility in water soluble in methanol, ethanol, sodium carbonate mg/mL (20 °C)
 YesY (what is this?)  (verify)

Florantyrone (INN; also known as Fluorantyrone) is a drug used in the treatment of biliary dyskinesia. It is also known as a cholagogue and choleretic.[1]

It is manufactured from fluoranthene and succinic anhydride in the presence of aluminum chloride in a nitrobenzene solution. (US PATENT 2,560,425 (1951 To Miles Lab)).