Title: Fluacizine
CAS Registry Number: 30223-48-4
CAS Name: 10-[3-(Diethylamino)-1-oxopropyl]-2-(trifluoromethyl)-10H-phenothiazine
Additional Names: 10-(N,N-diethyl-b-alanyl)-2-(trifluoromethyl)phenothiazine; fluoracisine; fluoracizine; ftoracizine
Trademarks: Phtorazisin (Medexport)
Molecular Formula: C20H21F3N2OS
Molecular Weight: 394.45
Percent Composition: C 60.90%, H 5.37%, F 14.45%, N 7.10%, O 4.06%, S 8.13%
Literature References: Phenothiazine derivative with psychotropic activity. Prepn: Y. I. Vikhlyaev et al., SU 360342 (1972), C.A. 78, 97683w (1973); of hydrochloride: S. V. Zhuravlev et al., GB 1191800 (1970), C.A. 73, 25493h (1970); Y. I. Vikhlyaev et al., FR 2035748 (1971), C.A. 75, 140872j (1971); eidem, DE 1805659 (1979), C.A. 75, 49101w (1971). Use as antidepressant: eidem, SU 356992 (1972), C.A. 78, 75888q (1973) (all to Inst. Pharmacol. Chemother., Acad. Med. Sci., USSR). Mass spectrum: S. Morosawa et al., Org. Mass Spectrom. 17, 309 (1982). Effect on drug metabolism: V. Avakumov et al., Biochem. Pharmacol. 27, 2177 (1978). Pharmacokinetics in animals, man: V. P. Zherdev et al., Farmakol. Toksikol. (Moscow) 45, 83 (1982).
Derivative Type: Hydrochloride
Additional Names: Fluoracyzine; toracizin
Molecular Formula: C20H21F3N2OS.HCl
Molecular Weight: 430.91
Percent Composition: C 55.75%, H 5.15%, F 13.23%, N 6.50%, O 3.71%, S 7.44%, Cl 8.23%
Properties: White cryst powder, mp 163-165°. Sol in water, warm alcohols.
Melting point: mp 163-165°
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.
Fluanisone Fluazacort Fluazifop-butyl Fluazinam Flubendazole

Fluacizine structure.svg
Systematic (IUPAC) name
Clinical data
Legal status Prescription only
Routes Oral, IM
CAS number 30223-48-4
ATC code None
PubChem CID 161562
ChemSpider 141910 YesY
UNII E2M3325B1R YesY
Chemical data
Formula C20H21F3N2OS 
Mol. mass 394.455 g/mol
 YesY (what is this?)  (verify)

Fluacizine (Phthorazisin), also known as fluoracizine and ftoracizine, is a phenothiazine derivative which, unlike most other phenothiazines which are used as antipsychotics, is an antidepressant with sedative effects that was marketed in Russia.[1][2][3][4] It is known to act as a norepinephrine reuptake inhibitor, antihistamine, and anticholinergic.[1][5][6][7]