Fluanisone

Title: Fluanisone
CAS Registry Number: 1480-19-9
CAS Name: 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone
Additional Names: 4¢-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]butyrophenone; haloanisone
Manufacturers' Codes: R-2028
Trademarks: Sedalande (J & J)
Molecular Formula: C21H25FN2O2
Molecular Weight: 356.43
Percent Composition: C 70.76%, H 7.07%, F 5.33%, N 7.86%, O 8.98%
Literature References: Prepn: Janssen, US 2997472 (1961). Determn in human plasma: M. P. Quaglio, A. M. Bellini, Farmaco Ed. Prat. 36, 204 (1981). Comparison between biochemical and behavioral effects: G. B. Fregnan, R. Porta, Arzneim.-Forsch. 31, 70 (1981). Toxicity study: C. Cascio et al., Farmaco Ed. Sci. 35, 605 (1980).
Properties: Crystals, mp 67.5-68.5°. Sol in chloroform; sparingly sol in methanol; slightly sol in ether. Practically insol in water. LD50 i.p. in mice: 200 mg/kg (Cascio).
Melting point: mp 67.5-68.5°
Toxicity data: LD50 i.p. in mice: 200 mg/kg (Cascio)
Derivative Type: Hydrochloride
Properties: mp 205-205.5°.
Melting point: mp 205-205.5°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Butyrophenones.
Fluazacort Fluazifop-butyl Fluazinam Flubendazole Flubenzimine

Fluanisone
Fluanisone structure.png
Systematic (IUPAC) name
1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one
Clinical data
Legal status  ?
Identifiers
ATC code N05AD09
PubChem CID 15139
ChemSpider 14410 YesY
UNII 1D0W98U1I4 YesY
KEGG D02621 YesY
ChEMBL CHEMBL58792 YesY
Chemical data
Formula C21H25FN2O2 
Mol. mass 356.43 g/mol
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Fluanisone is a typical antipsychotic and sedative of the butyrophenone chemical class. It is used in the treatment of schizophrenia and mania.

Fluanisone Syn.png

U.S. Patent 2,997,472