Flubendazole

Title: Flubendazole
CAS Registry Number: 31430-15-6
CAS Name: [5-(4-Fluorobenzoyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Additional Names: 5-(p-fluorobenzoyl)-2-benzimidazolecarbamic acid methyl ester
Manufacturers' Codes: R-17889
Trademarks: Flubenol (J & J); Flumoxal (Janssen); Fluvermal (Janssen)
Molecular Formula: C16H12FN3O3
Molecular Weight: 313.28
Percent Composition: C 61.34%, H 3.86%, F 6.06%, N 13.41%, O 15.32%
Literature References: Fluoro analog of mebendazole, q.v. Prepn: J. L. H. Van Gelder et al., DE 2029637; eidem, US 3657267 (1971, 1972 both to Janssen); A. H. M. Raeymaekers et al., Arzneim.-Forsch. 28, 586 (1978). Pharmacological, biological properties: D. Thienpont et al., ibid. 605. Anthelmintic activity in rats: O. Vanparijs et al., Vet. Parasitol. 5, 237 (1979); in pigs: E. Telléz-Giron et al., Am. J. Trop. Med. Hyg. 30, 135 (1981).
Properties: Crystals, mp 260°. LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont).
Melting point: mp 260°
Toxicity data: LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont)
Therap-Cat-Vet: Anthelmintic.
Flubenzimine Flucarbazone Fluchloralin Flucloronide Flucycloxuron

Flubendazole
Flubendazole.png
Systematic (IUPAC) name
Methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Identifiers
CAS number 31430-15-6 YesY
ATC code P02CA05 QP52AC12
PubChem CID 35802
UNII R8M46911LR N
KEGG D04200 YesY
ChEBI CHEBI:77095 N
ChEMBL CHEMBL145946 N
Chemical data
Formula C16H12FN3O3 
Mol. mass 313.28 g/mol
 N (what is this?)  (verify)

Flubendazole is an anthelmintic. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are Flubenol, Biovermin, and Flumoxal.[1]

It is also available for human use to treat worm infections. It is available OTC (without prescription) in Europe.