||This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. (September 2013)|
|Systematic (IUPAC) name|
|Pregnancy cat.||B3 (AU) C (US)|
|Legal status||POM (UK) ℞-only (US)|
|Bioavailability||75 to 90% (oral)|
|Protein binding||2.9 to 4%|
|Metabolism||Minimal, in the GI tract|
|Half-life||2.4 to 4.8 hours|
|Mol. mass||129.093 g/mol|
|(what is this?)|
Flucytosine, or 5-fluorocytosine, a fluorinated pyrimidine analogue, is a synthetic antimycotic drug.
It is structurally related to the cytostatic fluorouracil and to floxuridine. It is available in oral and in some countries also in injectable form. A common brand name is Ancobon. Flucytosine was first synthesized in 1957 but its antifungal properties were discovered in 1964. The drug is dispensed in capsules of 250 mg and 500 mg strength. The injectable form is diluted in 250 mL saline solution to contain 2.5 g total (10 mg/mL). The solution is physically incompatible with other drugs including amphotericin B.