Fluocinolone Acetonide

Title: Fluocinolone Acetonide
CAS Registry Number: 67-73-2
CAS Name: (6a,11b,16a)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
Additional Names: 6a,9a-difluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; 6a,9a-difluoro-16a-hydroxyprednisolone 16,17-acetonide; 6a,9a-difluoro-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione
Trademarks: Coriphate (Tokyo Tanabe); Cortiplastol (Medici); Dermalar; Fluonid (Allergan); Fluovitef (Italfarmaco); Fluvean (Kowa); Fluzon (Taisho); Jellin (Grenthal); Localyn (Syntex); Synalar (Syntex); Synamol (Syntex); Synandone (Syntex); Synemol (Syntex); Synotic (Syntex); Synsac (Syntex)
Molecular Formula: C24H30F2O6
Molecular Weight: 452.49
Percent Composition: C 63.70%, H 6.68%, F 8.40%, O 21.22%
Literature References: Prepn: J. S. Mills et al., J. Am. Chem. Soc. 82, 3399 (1960); J. S. Mills, A. Bowers, US 3014938; H. J. Ringold et al., US 3126375 (1961, 1964 both to Syntex). IR spectrum: Sammul et al., J. Assoc. Off. Agric. Chem. 47, 952 (1964).
Properties: Crystals from acetone + hexane, mp 265-266°. [a]D +95° (chloroform). uv max: 238 nm (log e 4.21).
Melting point: mp 265-266°
Optical Rotation: [a]D +95° (chloroform)
Absorption maximum: uv max: 238 nm (log e 4.21)
Therap-Cat: Glucocorticoid; anti-inflammatory.
Therap-Cat-Vet: Adrenocortical steroid (topical use).
Keywords: Glucocorticoid.
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