Fluoroacetic Acid

Title: Fluoroacetic Acid
CAS Registry Number: 144-49-0
Additional Names: Fluoroethanoic acid; gifblaar poison
Molecular Formula: C2H3FO2
Molecular Weight: 78.04
Percent Composition: C 30.78%, H 3.87%, F 24.34%, O 41.00%
Line Formula: CH2FCOOH
Literature References: Tricarboxylic acid cycle inhibitor. Toxic constituent of the poisonous South African plant, gifblaar, Dichapetalum cymosum (Hook.) Engl. (Chailletia cymosa Hook.), Dichapetalaceae; also contained in other poisonous plant species. Prepn: F. Swarts, Bull. Soc. Chim. [3] 15, 1134 (1896); Gryszkiewicz-Trochimowski et al., Rec. Trav. Chim. 66, 419 (1947). Review and biochemical aspects: Peters, Endeavour 13, 147 (1954); Peters et al., Biochem. J. 77, 17 (1960). Review of toxicity: Gribble, J. Chem. Educ. 50, 460-462 (1973); and properties: A. J. Elliott in Kirk-Othmer Encyclopedia of Chemical Technology vol. 11 (Wiley-Interscience, New York, 4th ed., 1994) pp 544-550.
Properties: Crystals. Burns with a green flame. mp 33°. bp 165°.
Melting point: mp 33°
Boiling point: bp 165°
Derivative Type: Sodium salt
CAS Registry Number: 62-74-8
Additional Names: Sodium fluoroacetate
Manufacturers' Codes: compound 1080
Trademarks: 1080 (Tull); Fratol
Molecular Formula: C2H2FNaO2
Molecular Weight: 100.02
Percent Composition: C 24.02%, H 2.02%, F 18.99%, Na 22.99%, O 31.99%
Properties: Hygroscopic white solid. mp 200-202° (dec when heated above mp). Soly at 25° (g/100g): water 111, methanol 5, ethanol 1.4, acetone 0.04, carbon tetrachloride 0.004.
Melting point: mp 200-202° (dec when heated above mp)
Derivative Type: Methyl ester
CAS Registry Number: 453-18-9
Molecular Formula: C3H5FO2
Molecular Weight: 92.07
Percent Composition: C 39.14%, H 5.47%, F 20.63%, O 34.75%
Properties: Liq, odor of ethyl acetate. d415 1.1613. bp 104.5°. Sol in water; slightly sol in petr ether.
Boiling point: bp 104.5°
Density: d415 1.1613
Derivative Type: Ethyl ester
CAS Registry Number: 459-72-3
Molecular Formula: C4H7FO2
Molecular Weight: 106.10
Percent Composition: C 45.28%, H 6.65%, F 17.91%, O 30.16%
Properties: Liq, odor of ethyl acetate. d20.5 1.0926. bp758 121.6°. nD20.5 1.3767. Sol in water.
Boiling point: bp758 121.6°
Index of refraction: nD20.5 1.3767
Density: d20.5 1.0926
CAUTION: Potential symptoms of overexposure to sodium fluoroacetate are vomiting; apprehension, auditory halucinations; facial paresthesia; twitching facial muscles; pulsus alternans, ectopic heartbeat, tachycardia, ventricular fibrillation; pulmonary edema; nystagmus; convulsions; liver, kidney damage. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 282; Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section III, pp 193-196.
Use: Sodium salt as water-soluble rodenticide.
Fluorobenzene Fluoroform Fluoromethane Fluorometholone Fluorosalan