Fluproquazone

Title: Fluproquazone
CAS Registry Number: 40507-23-1
CAS Name: 4-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone
Additional Names: 1-isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone
Manufacturers' Codes: RF-46-790
Trademarks: Tormosyl
Molecular Formula: C18H17FN2O
Molecular Weight: 296.34
Percent Composition: C 72.95%, H 5.78%, F 6.41%, N 9.45%, O 5.40%
Literature References: Fluoro analog of proquazone, q.v. Prepn: G. E. Hardtmann et al., DE 2230393 (1973 to Sandoz), C.A. 78, 111363a (1973); G. E. Hardtmann, US 3937705 (1976 to Sandoz). Analgesic effect: U. Herrmann et al., Clin. Pharmacol. Ther. 27, 379 (1980); B. von Graffenried, E. Nuesch, Br. J. Clin. Pharmacol. 10, Suppl. 2, 225 (1980). Series of articles on pharmacology, metabolism, analysis, clinical studies, toxicology: Arzneim.-Forsch. 31, 871-940 (1981). Toxicity: G. Rüttimann et al., Arzneim.-Forsch. 31, 882 (1981).
Properties: Crystals, mp 172-174°. LD50 in mice, rats, rabbits (mg/kg): >5000, >3000, 742 orally (Rüttimann).
Melting point: mp 172-174°
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): >5000, >3000, 742 orally (Rüttimann)
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic).
Fluprostenol Flupyrsulfuron-methyl Fluquinconazole Flurandrenolide Flurazepam

Fluproquazone
Fluproquazone.svg
Systematic (IUPAC) name
4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
Clinical data
Legal status  ?
Identifiers
CAS number 40507-23-1
ATC code None
PubChem CID 38503
ChemSpider 35289 YesY
UNII U4K85O58HD YesY
KEGG D04229 YesY
Chemical data
Formula C18H17FN2O 
Mol. mass 296.339 g/mol
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Fluproquazone (trade name Tormosyl) is a quinazolinone derivative with potent analgesic[1][2] and antipyretic[3] effects and also anti-inflammatory action. It has been shown to be effective in a variety of animal species after both oral and parenteral administration, and has a duration of action of several hours. The compound is many times more potent than acetylsalicylic acid and clinically generally resembles ibuprofen and indoprofen in its pharmacological effects, but with significantly less ulcerogenic activity.[4] It is mainly used in the treatment of arthritis[5] and post-operative pain.[6]