Flurandrenolide

Title: Flurandrenolide
CAS Registry Number: 1524-88-5
CAS Name: (6a,11b,16a)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
Additional Names: 6a-fluoro-11b,16a,17,21-tetrahydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal with acetone; 6a-fluoro-16a,17a-isopropylidenedioxy-4-pregnene-11b,21-diol-3,20-dione; 6a-fluoro-11b,16a,17,21-tetrahydroxyprogesterone cyclic 16,17-acetal with acetone; fludroxycortide; fluorandrenolone; flurandrenolone; flurandrenolone acetonide
Trademarks: Cordran (Watson); Drenison (Lilly); Drocort (Lilly); Sermaka (Lilly)
Molecular Formula: C24H33FO6
Molecular Weight: 436.51
Percent Composition: C 66.04%, H 7.62%, F 4.35%, O 21.99%
Literature References: Prepn: H. J. Ringold et al., DE 1131213; eidem, US 3126375 (1962, 1964 both to Syntex). HPLC determn in pharmaceutical cream: R. Pearlman et al., Int. J. Pharm. 18, 53 (1984); in urine: E. Neufeld et al., J. Chromatogr. B 718, 273 (1998). Clinical trial in psoriasis: G. G. Krueger et al., J. Am. Acad. Dermatol. 38, 186 (1998).
Properties: Crystals from acetone + hexane, mp 247-255°. [a]D +140-150° (CHCl3). uv max: 236 nm (log e 4.17).
Melting point: mp 247-255°
Optical Rotation: [a]D +140-150° (CHCl3)
Absorption maximum: uv max: 236 nm (log e 4.17)
Therap-Cat: Glucocorticoid; antipsoriatic.
Keywords: Glucocorticoid; Antipsoriatic.
Flurazepam Flurogestone Acetate Flurothyl Fluroxene Fluroxypyr

Fludroxycortide
Fludroxycortide.svg
Systematic (IUPAC) name
6-Fluoro-11,21-dihydroxy-16,17-[(l-methylethylidene)bis(oxy)]-(6α,11β,16α)-pregn-4-ene-3,20-dione
Clinical data
Trade names Cordran, Haelan
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status POM (UK)
Routes Topical
Identifiers
CAS number 1524-88-5 YesY
ATC code D07AC07
PubChem CID 15209
DrugBank DB00846
ChemSpider 14475 YesY
UNII 8EUL29XUQT YesY
KEGG D00328 YesY
ChEMBL CHEMBL1201012 N
Chemical data
Formula C24H33FO6 
Mol. mass 436.514 g/mol
 N (what is this?)  (verify)

Fludroxycortide (INN, also known as flurandrenolone or flurandrenolide[1]) is a synthetic topical steroid and is used as an anti-inflammatory treatment for use on skin irritations. Trade names include Haelan (Typharm, UK) and Cordran (by Watson Pharmaceuticals, US).[2][3]

Fludroxycortide is available in ointment, cream and as an impregnated tape (Haelan tape, Cordran tape). Licensed indications in the United Kingdom include recalcitrant dermatoses.[4][5]